【摘要】 在老年人、糖尿病以及慢性肾衰竭人群中，骨质流失和血管钙化常同时存在。越来越多的证据表明，血管钙化与骨质流失可能存在共同的病理生理机制，血管钙化与骨代谢存在高度临床相关性。血管钙化是钙和磷酸盐沉积的过程，血管平滑肌细胞（VSMC）在多种理化因素的作用下丧失收缩表型，最终完全转变为成骨细胞。血清甲状旁腺素（PTH）、磷、维生素K、基质Gla蛋白（MGP）等与RANK/RANKL/OPG系统和Wnt/β-catenin通路相互作用。血管钙化与骨质流失的关系错综复杂，涉及多种通路、因子、内环境及局部微环境等的改变，对其作用机制的研究，将有利于血管钙化早期诊断和治疗。基于此，本文对血管钙化与骨质流失的关系展开综述，深入了解其病理生理机制。更多还原

【Abstract】 Bone loss and vascular calcification often co-exist in the elderly, diabetic and chronic renal failure patients. More and more evidence shows that vascular calcification and bone loss may have a common pathophysiological mechanism, and there is a high clinical correlation between vascular calcification and bone metabolism. Vascular calcification is a process of calcium and phosphate deposition. Vascular smooth muscle cell(VSMC) lose contractile phenotype under the action of various physical and chemical factors, and eventually completely transform into osteoblasts. Serum parathyroid hormone(PTH), phosphorus, vitamin K and matrix Gla protein(MGP) interact with the RANK/RANKL/OPG system and the Wnt/β-catenin pathway.The relationship between vascular calcification and bone loss is complex, involving a variety of pathways,factors, internal environment and local microenvironment changes. The study of its mechanism of action will be conducive to the early diagnosis and treatment of vascular calcification. Based on this, this paper reviews the relationship between vascular calcification and bone loss, and deeply understands its pathophysiological mechanism.更多还原