【摘要】 目的：探讨肺结核(TB)合并2型糖尿病(T2DM)患者的耐多药结核分枝杆菌(MDR-MT)类型及危险因素。方法：选取2019年7月—2024年4月湛江中心人民医院医治的247例TB合并T2DM患者作为研究对象，统计MDR-MT的构成比及类型。采用二元logistic回归分析产生MDR-MT的危险因素。结果：MDR-MT的构成比为25.10%(62株)。MDR-MT的类型有11种，其中对链霉素(SM)、异烟肼(INH)、利福平(RFP)、乙胺丁醇(EMB)同时耐药占22.58%(14株)，对SM、INH、RFP、EMB、左氧氟沙星(LFX)同时耐药占16.13%(10株)。二元logistic回归分析显示，复治患者、糖化血红蛋白≥7%、糖尿病并发症、文化程度为高中及以下、低蛋白血症为产生MDR-MT的危险因素。结论：TB合并T2DM患者的MDR-MT的耐药形势严峻，类型众多，以对STR、INH、RFP、EMB同时耐药最为常见。复治患者、糖化血红蛋白≥7%、糖尿病并发症、文化程度为高中及以下、低蛋白血症是产生MDR-MT的独立危险因素。更多还原

【Abstract】 Objective:To investigate the the types and risk factors of multidrug-resistant mycobacterium tuberculosis (MDR-MT) in patients with tuberculosis (TB) and type 2 diabetes (T2DM).Method:247 TB patients with T2DM treated in Central People’s Hospital of Zhanjiang from July 2019 to April 2024 were selected as the study objects,and the composition ratio and type of MDR-MT were analyzed.The risk factors of MDR-MT were analyzed by binary logistic regression.Result:The proportion of MDR-MT was 25.10% (62 strains).There were 11 types of MDR-MT,of which 22.58% (14 strains) were simultaneously resistant to streptomycin (SM),isoniazid (INH),rifampicin (RFP) and ethambutol (EMB),and 16.13% (10 strains) were simultaneously resistant to SM,INH,RFP,EMB and Levofloxacin (LFX).Binary logistic regression analysis showed that retreated patients,HBA1c ≥7%,diabetes complications,education level of high school or below all were risk factors for MDR-MT.Conclusion:There are many types of MDR-MT drug resistance in TB patients with T2DM,and simultaneous resistance to STR,INH,RFP and EMB is the most common.The independent risk factors for MDR-MT were retreated patients,HBA1C ≥7%,diabetic complications,high school education or below,and hypoproteinemia.更多还原