【摘要】 妊娠期肝内胆汁淤积症（ICP）是妊娠中晚期常见的疾病，对母婴健康有很大的威胁。尽管已有广泛的研究表明该疾病的发生与免疫、遗传、环境、激素因素等密切相关，但其发病机制仍不明确，近年来成纤维细胞生长因子（FGF）在ICP发病机制中所起的作用及能否作为ICP的生物标志物成为研究热点。本文通过检索ICP和FGF相关文献，从多个体内代谢机制方面入手，阐述FGF19和FGF21与ICP发病机制之间的联系。更多还原

【Abstract】 Intrahepatic cholestasis of pregnancy(ICP) is a common disease in the middle and late pregnancy, which poses a great threat to maternal and infant health. Although extensive studies have shown that the occurrence of the disease is closely related to immune,genetic, environmental and hormonal factors, its pathogenesis is still unclear. In recent years, the role of fibroblast growth factor(FGF) in the pathogenesis of ICP and whether it can be used as a biomarker of ICP have become a focus of research. In this paper, the relationship between FGF19 and FGF21 and the pathogenesis of ICP was discussed in terms of multiple metabolic mechanisms in vivo by searching relevant literatures of ICP and FGF.更多还原