【摘要】 目的：研究亚甲蓝（Methylene Blue,MB）注射液治疗感染性休克的效果。方法：选取2021年7月—2022年6月茂名市人民医院收治的80例感染性休克患者为研究对象。根据随机数表法将其分为对照组和观察组，各40例。对照组给予常规治疗，观察组在对照组基础上给予MB注射液。比较两组治疗前（T₀）、治疗1 d后（T₁）、治疗3 d后（T₂）、治疗5 d后（T₃）、治疗7 d后（T₄）的平均动脉压（mean arterial pressure,MAP）、心率（heart rate,HR）、外周血管阻力指数（systemic vascular resistance index,SVRI）、肺血管阻力指数（pulmonary vascular resistance index,PVRI）、心脏指数（cardiac index,CI）及无创脉搏氧灌注指数（noninvasive pulse oxygen perfusion index,PI），治愈率及不良反应。结果：T₂、T₃、T₄，观察组MAP、HR、SVRI、PVRI、CI、PI均高于对照组，差异有统计学意义（P<0.05）。观察组的治愈率为85.00%（34/40），高于对照组的62.50%（25/40），差异有统计学意义（χ²=5.230,P=0.022）。观察组不良反应发生率与对照组比较，差异无统计学意义（P>0.05）。结论：MB注射液治疗感染性休克能够获得更高的治愈率，有效改善患者机体的血流动力学，治疗安全性较好。更多还原

【Abstract】 Objective:To study the effect of Methylene Blue （MB） Injection in the treatment of septic shock.Method:A total of80 patients with septic shock admitted to Maoming People’s Hospital from July 2021 to June 2022 were selected as the study objects.They were divided into control group and observation group according to random number table method,with 40 cases in each group.The control group received conventional treatment,and the observation group received MB Injection on the basis of the control group.The mean arterial pressure （MAP） and heart rate （heart rate）,systemic vascular resistance index （SVRI）,pulmonary vascular resistance index （PVRI）,cardiac index （CI）,noninvasive pulse oxygen perfusion index （PI） before treatment （T₀）,after 1 d of treatment （T₁）,after 3 d of treatment（T₂）,after 5 d of treatment （T₃） and after 7 d of treatment （T₄）,cure rate and adverse reactions of the two groups were compared.Result:T₂,T₃,T₄,MAP,HR,SVRI,PVRI,CI,PI in observation group were higher than those in control group,and the differences were statistically significant （P<0.05）.The cure rate of observation group was 85.00%（34/40）,which was higher than 62.50%（25/40） of control group,the difference was statistically significant （χ²=5.230,P=0.022）.There was no significant difference in the incidence of adverse reactions between the observation group and the control group （P>0.05）.Conclusion:MB Injection in the treatment of septic shock can obtain a higher cure rate,effectively improve the patient’s body hemodynamics,treatment safety is good.更多还原