【摘要】 锰因其相对丰度高、价格低廉、环境友好等特点而在催化环丁醇的C—C键断裂官能化反应研究中备受关注.报道了一例锰催化环丁醇开环C—C键氟化反应.该反应在温和的条件下,以10 mol%的Mn（OAc）₂作为催化剂, HF·Et₃N和PhIO作用原位生成的亲电氟化试剂作为氟源,为直接合成γ-氟化酮提供了一种有效的途径.该反应具有优异的官能团耐受性,并显示出广泛的底物范围,能够以50%～76%的产率得到相应的产物.更多还原

【Abstract】 Manganese-catalyzed C—C bond cleavage of cyclobutanols has attracted great attention due to the high abundance and cheap and eco-friendly behaviour. A manganese-catalyzed ring-opening C—C bond fluorination of cyclobutanols is reported. Under mild conditions, the reaction provides a straightforward access to γ-fluorinated ketones using 10 mol% Mn（OAc）₂ as catalyst and electrophilic fluorination reagent, which was generated in situ from HF·Et₃N and PhIO, as fluorine source. The reaction has an excellent functional-group tolerance and displays a broad substrate scope, affording the corresponding products in 50%～76% yields.更多还原