【摘要】 发展了一种无金属、无外加化学氧化剂的条件下,电化学氧化α-酮酸脱羧与邻氨基苄胺的高效环化反应合成喹唑啉类化合物的方法.该方法反应条件温和,底物适用范围广,以中等到优良的产率得到相应的产物.同时,该方法也可以用于苯并噁唑、苯并噻唑和苯并咪唑等杂环的合成.更多还原

【Abstract】 A novel method for synthesizing quinazolines by an electrochemical oxidation decarboxylative cyclization reaction of α-keto acid with o-aminobenzylamine under metal and external chemical oxidants free conditions was developed. This method has mild reaction conditions, and can tolerate a wide range of functional groups, and can provide the corresponding products with moderate to excellent yields. Furthermore, the method can also be used for the synthesis of other heterocycles such as benzoxazole, benzothiazole and benzimidazole.更多还原