【摘要】 目的 对钛网及3D打印金属椎体替代物力学性能进行研究，为临床中人工椎体选择与结构优化设计提供指导。方法 通过压缩力学测试，对钛网及3D打印多孔型、桁架型与拓扑型椎体替代物的等效力学属性与结构破坏形式进行系统研究。结果 钛网等效弹性模量[(2 908.73±287.39) MPa]仅次于拓扑型椎体替代物，但其结构强度与稳定性较差，等效屈服强度[(46.61±4.85) MPa]高于多孔型椎体替代物，且在压缩中率先屈服；多孔型椎体替代物结构强度[(18.14±0.17)～(25.79±0.40) MPa)]不足，难以满足脊柱重建力学要求；桁架型椎体替代物等效弹性模量[(2 477.86±55.19)～(2 620.08±194.36)MPa]与等效屈服强度[(77.61±0.50)～(88.42±1.07) MPa]良好但稳定性不足，在压缩过程中容易出现失稳现象；拓扑型椎体替代物具有最高的等效弹性模量[(3 746.28±183.80) MPa]与等效屈服强度[(177.43±3.82) MPa],可为人工椎体在体服役安全稳定提供更强保障。结论 拓扑优化方法可实现椎体替代物高强度、高稳定性设计，提供更大的设计空间与安全余量，为人工椎体轻量化与新材料设计提供更多可能。更多还原

【Abstract】 Objective To study the mechanical properties of titanium mesh and three-dimensional(3D)-printed metal vertebral body substitutes(VBS) to provide guidance for the selection and structural optimization of artificial vertebral implants in clinical practice. Methods The equivalent elastic modulus, equivalent yield strength, and structural failure mode of titanium mesh and 3D-printed porous, truss, and topologically optimized VBS were systematically investigated using compression tests. Results The elastic modulus of the titanium mesh(2 908.73±287.39 MPa) was only lower than that of the topologically optimized VBS. However, their structural strengths and stabilities were inadequate. The yield strength of the titanium mesh(46.61±4.85 MPa) was only higher than that of the porous VBS and it was the first to yield during compression. The porous VBS was insufficient for use as the vertebral implant owing to its poor mechanical strength(18.14±0.17 MPa-25.79±0.40 MPa). The truss VBS had good elastic modulus(2 477.86±55.19 MPa-2 620.08±194.36 MPa) and strength(77.61±0.50 MPa-88.42±1.07 MPa). However, the structural stability of the truss VBS was insufficient, and instability occurred easily during compression. The topologically optimized VBS had the highest elastic modulus(3 746.28±183.80 MPa) and yield strength(177.43±3.82 MPa) among all the tested VBS types, which could provide improved security and stability for artificial vertebral implant in vivo services. Conclusions Topology optimization results in a high strength and high stability VBS design. Moreover, it provides a large design space and great safety margin to provide increased possibilities for lightweight and new material design of future artificial vertebral implants.更多还原