【摘要】 目的 探索内毒素性实热证猕猴视网膜血管直径的变化。方法 本研究采用内毒素肌肉注射建立猕猴实热证模型；造模成功后，利用Oxymap设备采集眼底图片，并对视网膜动、静脉直径进行分析；实热证组和对照组的直径大小变化数据分析采用独立样本t检验。结果 内毒素性实热证猕猴模型造模成功。实热证组与对照组相比静脉、鼻侧动脉直径明显缩小(P<0.05);而颞上动脉和颞下动脉直径虽有不同程度缩小(P>0.05)。结论 内毒素性实热证猕猴的视网膜血管直径会呈现不同程度的收缩。视网膜血管直径具有成为中医证候定量指标的潜力。更多还原

【Abstract】 Objective To explore the changes of retinal vessel diameter of rhesus monkeys with endotoxin-induced excess heat syndrome. Methods In this study, we established an experimental pyrexia macaque model by intramuscularly injecting endotoxin. After successful modeling, Oxymap was used to capture fundus images of the macaques, and subsequent analysis focused on assessing retinal artery and vein diameters. An independent samples t-test was employed to analyze the variations in diameter between the experimental and control groups.Results The experimental group exhibited a significant decrease in the diameter of both venous and nasal arteries compared to the control group(P<0.05). However, varying degrees of reduction were observed in the diameter of the superior temporal artery and inferior temporal artery(P>0.05).Conclusion In the state of endotoxic fever, rhesus monkeys exhibit varying degrees of constriction in their retinal arteries and veins, suggesting the potential utility of retinal vessel diameter as a quantitative indicator for syndromes in traditional Chinese medicine.更多还原