【摘要】 目的：采用两样本孟德尔随机化（MR）分析探究不同类型（心理被动性、心理主动性）久坐行为（看电视、使用计算机、驾驶）与消极情绪（抑郁、孤独、忧虑/焦虑）的因果关系，为久坐带来情绪健康问题制定干预策略。方法：基于已发表的全基因组关联数据库中久坐行为和消极情绪的相关类型，提取工具变量，运用逆方差加权作为主要孟德尔随机化分析方法，通过敏感度分析、异质性检验、水平基因多效性等方法检验结果的稳健性。结果：1)看电视能够增加抑郁和孤独情绪发生的比例[OR=1.08,95%CI（1.04,1.12）,P=3.52×10^-5;OR=1.18,95%CI（1.10,1.25）,P=1.83×10^-7]。2)驾驶能够降低抑郁和忧虑/焦虑情绪发生的比例[OR=0.88,95%CI（0.80,0.97）,P=0.01;OR=0.76,95%CI（0.70,0.83）,P=1.34×10^-10]。3)使用计算机能够降低忧虑/焦虑情绪发生的比例[OR=0.95,95%CI（0.91,0.99）,P=0.02]。4)多变量MR分析显示，控制BMI、失眠、受教育年限、剧烈运动后整体上未改变上述因果关系。结论：久坐行为和消极情绪间存在因果关联，看电视（心理被动性久坐行为）增加抑郁、孤独情绪；使用计算机（心理主动性久坐行为）和驾驶（心理主动性久坐行为）分别缓解忧虑/焦虑情绪、抑郁和忧虑/焦虑情绪。更多还原

【Abstract】 Objective To explore the causal relationship between sedentary behaviors（television watching,computer use,and driving） of different types（active and passive） and negative emotional states（depression, loneliness and worry/anxiety）, so as to address emotional health issues associated with sedentary behavior. Methods Based on the correlation types of sedentary behavior and negative emotion in the published genome-wide association studies（GWAS）,the instrumental variables were extracted,and inverse variance weighted was used as the main Mendelian randomization analysis method. The stability and reliability of the results were tested using sensitivity analysis,heterogeneity test,and horizontal gene pleiotropy. Results Watching TV increased the incidence of depression and loneliness[OR=1.08,95%CI（1.04,1.12）,P=3.52×10^-5; OR=1.18,95%CI（1.1,1.25）,P=1.83×10-^-7],while driving reduced that of depression and worry/anxiety [OR=0.88,95%CI（0.80,0.97）,P=0.01; OR=0.76,95% CI（0.70, 0.83）, P=1.34 × 10^-10]. Moreover, computer use lowered the incidence of worry/anxiety [OR=0.95,95%CI（0.91,0.99）; P=0.02]. However,the results of the multivariate MR showed that controlling of BMI and insomnia,as well as increasing vigorous physical activity and education duration,did not alter the above causal relationships. Conclusion There is a causal association between sedentary behaviors and negative emotional states. Mentally-passive sedentary behaviors,such as watching TV,increase depression and loneliness. However,mentally-active sedentary behaviors,such as computer use relieve anxiety/worry,whereas driving alleviates both depression and anxiety/worry.更多还原