【摘要】 目的 探讨应用T₂mapping量化比较急性前交叉韧带（ACL）损伤患者患侧与正常侧关节软骨基质的变化。方法 选取急性及亚急性ACL损伤患者（创伤后平均32天）30例，患者均进行双侧膝关节MRI检查，包括常规MRI检查及T₂mapping序列，之后对胫股关节不同部位深浅层关节软骨进行测量T₂值及关节软骨厚度，运用配对t检验评估患侧及正常关节软骨的差异。结果 与正常膝关节相比，患侧外侧缘浅表股骨中央前部、股骨后缘后部，外侧缘深层股骨后缘后部，内侧缘浅表股骨前缘后部，内侧缘深层股骨中央后部、胫骨前部、胫骨中央、胫骨后部等部位患侧关节软骨T₂值明显较高，差异具有统计学意义（P<0.05）。患侧内外侧缘深浅层关节软骨T₂值相比，除了外侧缘股骨后缘后部及内侧缘股骨前缘后部外，其余所有部位浅层T₂值较深层明显较高，差异具有统计学意义（P<0.05）。外侧缘浅表部位股骨前缘前部及内侧缘深层部位胫骨前部，患侧关节软骨T₂值较正常侧低，差异具有统计学意义（P<0.05）。内侧缘股骨前缘后部、胫骨后部等部位患侧关节软骨厚度较正常侧薄，差异具有统计学意义（P<0.05）。结论 ACL损伤患者患侧关节软骨多处T₂弛豫时间较对侧升高并且多处关节软骨变薄。ACL损伤是PTOA发生发展的重要原因。更多还原

【Abstract】 Objective To conduct a quantitative comparison of changes in the articular cartilage matrix between the affected and normal sides in patients with acute ACL injury using T₂ mapping.Methods Thirty patients with acute and subacute ACL injuries （average 32 days after trauma） were collected,and all patients underwent bilateral knee MRI examinations,including conventional MRI examinations and T₂mapping sequences,followed by measurement of deep and superficial articular cartilage in different parts of the tibiofemoral joint.T₂ values and articular cartilage thickness were measured,and the differences between the affected and normal articular cartilage were evaluated using paired t-tests.Results Compared with the normal side,T₂ values were higher in a CF,p PFlateral superficial zone,p PF in the deep zone,and p Tr in the medial superficial zone （P<0.05）.The T₂value of the articular cartilage on the affected side of a Tr at the superficial part of the lateral side and AT in medial deep zone was higher than that on the contralateral side （P<0.05）.Compared to the superficial and deep articular cartilage T₂ values at the affected medial and lateral side,the superficial articular cartilage T₂ values were significantly higher than the deep ones at all sites except for the lateral p PF and medial p Tr （P<0.05）.The thickness of p Tr,PT articular cartilage on the affected side of the medial side was lower than that on the normal side.All these differences were statistically significant （P<0.05）.Conclusion Patients with ACL injury have increased T₂ relaxation time and thinning of articular cartilage on several sites on the affected side compared to the contralateral side.ACL injury is an important cause of the development of PTOA.更多还原