【摘要】 呼出气一氧化氮（FeNO）是一种2型炎症标志物，在体内主要由气道上皮的一氧化氮合成酶（NOS以L-赖氨酸和氧气为底物合成。2型炎症细胞因子白介素（IL）-4和IL-13可以上调诱导型NOS，造成一氧化氮的大量产生，并在支气管哮喘的发病中起到重要作用。FeNO与气道炎症和重塑、肺功能的下降、嗜酸性粒细胞的浸润等密切相关。临床上FeNO的应用主要包括支气管哮喘的诊断、预测患者对激素的治疗反应以及依从性评估。近年来，FeNO在生物制剂的选择上也起到指示作用。作为一种无创、简便、经济的检测手段，FeNO在支气管哮喘诊治中的作用将会得到更多的认识和应用。更多还原

【Abstract】 Fractional exhaled nitric oxide(FeNO) is a biomarker of type 2 inflammation, and produced by nitric oxide synthase(NOS) expressed on the airway epithelial cells, with the substrates of L-arginine and oxygen. Type 2 cytokines such as interleukin(IL)-4 and IL-13 can up-regulate inducible NOS, which results in the abundant production of NO. NO plays an important role in the pathogenesis of bronchial asthma, and is closely associated with the airway inflammation and remodeling, reduction of lung function and eosinophil infiltration, etc. The technique of FeNO test is applied in the clinical diagnosis of asthma, predicting the response to steroids and evaluating the compliance of asthmatic patients. In recent years, it also plays a guiding role in choosing the optimal biologics for individual therapy for patients of asthma. As a non-invasive, convenient, and economical method, the role of FeNO in the diagnosis and treatment of asthma will be better understood and applied.更多还原