【摘要】 气道黏液高分泌是多种慢性气道疾病的重要病理生理及临床表现，是影响疾病预后及转归的独立危险因素。阿奇霉素可有效预防或减少慢性气道疾病急性加重，抑制慢性气道疾病气道黏液高分泌状态，但具体机制尚未完全明确，可能与阿奇霉素抑制黏蛋白MUC5AC的合成和分泌、抑制细菌生物膜形成等作用有关。该文总结了阿奇霉素抑制气道黏液高分泌的可能作用机制及其在慢性气道疾病的应用现状，以期为阿奇霉素的后续研究及临床应用提供诊疗参考。更多还原

【Abstract】 Airway mucus hypersecretion is an important pathophysiological and clinical manifestation of a variety of chronic airway diseases, and is an independent risk factor affecting the prognosis and outcome of the disease.Azithromycin can effectively prevent or reduce the acute exacerbation of chronic airway diseases and inhibit the hypersecretion of airway mucus in chronic airway diseases.However, the specific mechanism is not completely clear, which may be related to the inhibition of the synthesis and secretion of mucin MUC5AC and the inhibition of bacterial biofilm formation.This article summarizes the possible mechanism of azithromycin in inhibiting airway mucus hypersecretion and its application in chronic airway diseases, in order to provide reference for the follow-up study and clinical application of azithromycin.更多还原