【摘要】 目的:分析血清微小RNA(miR)-223水平、血小板参数及凝血指标与稳定型心绞痛(SAP)的相关性及对其的预测价值。方法:选择2019年1月至2021年1月新疆医科大学第一附属医院收治的150例SAP患者为SAP组，并选择150例非冠心病人群为对照组。比较两组miR-223、血小板参数及凝血指标水平，采用Spearman法分析上述指标与冠脉病变程度(Gensini评分)的相关性，ROC曲线分析miR-223、纤维蛋白原(Fg)对SAP的诊断价值。结果:与对照组比较，SAP组miR-223、纤维蛋白原、纤维蛋白原降解产物、D二聚体、血小板分布宽度水平显著升高，血小板计数水平显著降低(P<0.05或<0.01)。Spearman相关性分析结果显示，纤维蛋白原、miR-223与冠状动脉病变严重程度呈正相关(r=0.228、0.269,P=0.013,0.001)。ROC曲线分析结果显示，miR-223[曲线下面积(AUC)=0.851]、纤维蛋白原(AUC=0.692)对SAP有较好的预测价值。结论:血清miR-223、纤维蛋白原与冠脉病变严重程度相关，二者可作为稳定型心绞痛诊断、病情评估的参考指标。更多还原

【Abstract】 Objective:This study aims to analyze association of serum microRNA(miR)-223, platelet parameters and coagulation indicators with stable angina pectoris(SAP) and their predictive value for it.Methods:A total of 150 SAP patients admitted in First Affiliated Hospital of Xinjiang Medical University between January 2019 and January 2021 were enrolled as SAP group, another 150 subjects without coronary heart disease were selected as control group. MiR-223, platelet parameters and coagulation indicator levels were compared between two groups. Spearman method was used to analyze the association of above-mentioned indexes with severity of coronary artery disease(Gensini score), and ROC curve was used to analyze the diagnostic value of miR-223 and fibrinogen(Fg) for SAP. Results: Patients in SAP group had significant higher miR-223, Fg, Fg degradation products, D dimer and platelet distribution width, and significant lower platelet count compared to control group(P<0.05 or <0.01). Spearman correlation analysis indicated that Fg and miR-223 were positively correlated with severity of coronary artery disease(r=0.228, 0.269, P=0.013, 0.001). ROC curve analysis showed that miR-223 [area under the curve(AUC)=0.851]and Fg(AUC=0.692) had good predive value for SAP. Conclusion: Serum miR-223 and fibrinogen are associated with severity of coronary artery disease. They could be used as reference indexes for diagnosis and assessment of stable angina pectoris.更多还原