【摘要】 心血管疾病(CVD)是引起全球发病率和死亡率持续升高的慢性非传染性疾病，吸烟、肥胖和血脂异常等多因素共同参与其发病过程，对公共卫生构成了严重的威胁和挑战。因此，亟需探索新的有效风险预测因子及干预措施，准确识别高危患者，“前移”预防窗口，控制致病危险因素，延缓病程进展，这己成为防治CVD的根本。甘油三酯葡萄糖指数通过代谢及炎症反应等途径驱动动脉粥样硬化的形成，从而加剧向冠心病的演变过程；在血管内皮功能、血管紧张素原的异位合成、肾素-血管紧张素-醛固酮系统、交感神经系统及盐吸收中发挥作用，从而影响血压的变化；此外，随着胰岛素抵抗程度的增加，心脏脂肪酸利用率下降、AMPK/PGC-1信号转导通路损害及活性氧水平增加，从而导致心力衰竭。血小板与淋巴细胞比值是一种炎症标志物，通过血小板和淋巴细胞的变化在CVD中发挥作用。现结合最新研究对以上两个指标预测CVD的潜在价值进行综述。更多还原

【Abstract】 Cardiovascular disease(CVD) is a chronic non-infectious disease that causes the global incidence rate and mortality to continue to rise.Smoking, obesity, dyslipidemia and other factors participate in its pathogenesis, posing a serious threat and challenge to public health.Therefore, it is urgent to explore new effective risk prediction factors and intervention measures, accurately identify high-risk patients, move forward the prevention window, control pathogenic risk factors and delay disease progression, which have become the fundamental measures for preventing and treating CVD.Triglyceride-glucose index drives the formation of atherosclerosis through metabolic and inflammatory pathways, thus exacerbating the evolution to coronary heart disease.It also plays a role in vascular endothelial function, ectopic synthesis of angiotensinogen, renin-angiotensin-aldosterone system, sympathetic nervous system and salt absorption, thus affecting blood pressure changes.In addition, with the increase of insulin resistance, the utilization of cardiac fatty acids decreased, AMPK/PGC-1 signal transduction pathway impaired, and reactive oxygen species levels increased, leading to heart failure.The platelet-to-lymphocyte ratio is an inflammatory marker that plays a role in CVD through changes in platelets and lymphocytes.Based on the latest research, this article reviews the potential value of the above two indicators in predicting CVD.更多还原