【摘要】 目的 本研究探讨了miR-155-5p在大鼠急性心肌梗死模型中的保护作用。方法 通过向健康雄性SD大鼠注射空载体和miR-155-5p腺病毒，分为空载体模型组和miR-155-5p过表达组，研究其对心脏功能、心肌损伤指标和心肌细胞凋亡的影响。结果 结果显示，miR-155-5p过表达组的心脏功能显著改善，心肌损伤标志物降低，心肌梗死面积和细胞凋亡减少。进一步发现miR-155-5p过表达也能增强H9c2心肌细胞在缺氧条件下的存活能力，降低凋亡相关蛋白的表达。结论 这表明miR-155-5p的过表达可以有效保护心肌细胞，减轻急性心肌缺血引起的心肌损伤，有望成为心肌梗死治疗的新靶点。此研究为miR-155-5p在心肌梗死诊断和治疗中的应用提供了新的理论依据。更多还原

【Abstract】 Objective This study investigates the protective role of miR-155-5p in rat models of acute myocardial infarction.MethodsHealthy male SD rats were injected with either control vector or miR-155-5p adenovirus, forming control model groups and miR-155-5p overexpression groups, to study the effects on cardiac function, myocardial injury markers, and myocardial cell apoptosis.Results The results showed that the cardiac function of the miR-155-5p overexpression group significantly improved, myocardial injury markers were reduced, and the area of myocardial infarction and cell apoptosis were decreased.Additionally, overexpression of miR-155-5p also enhanced the survival ability of H9c2 cardiomyocytes under hypoxic conditions and reduced the expression of apoptosis-related proteins.Conclusion This indicates that the overexpression of miR-155-5p can effectively protect myocardial cells and alleviate myocardial damage caused by acute myocardial ischemia, potentially serving as a new target for the treatment of myocardial infarction.This study provides a new theoretical basis for the application of miR-155-5p in the diagnosis and treatment of myocardial infarction.更多还原