【摘要】 目的 采用两样本孟德尔随机化方法探讨高分贝音乐与6种心血管疾病之间的因果关系。方法 从全基因组关联研究数据库中分别筛出与高分贝音乐、高血压、缺血性脑卒中、冠状动脉粥样硬化、心肌梗死、心房颤动和心力衰竭相关的单核苷酸多态性作为遗传工具变量，使用逆方差加权法、MR-Egger法、加权中位数法3种孟德尔随机化分析方法评估高分贝音乐与心血管疾病之间的因果关系。同时采用Cochran’s Q检验、MR-Egger回归、MR-PRESSO分析、留一法4种方法进行敏感性分析。结果 逆方差加权法表明高分贝音乐与缺血性脑卒中呈正相关[OR(95%CI)=1.424(1.061～1.911),P <0.05]和冠状动脉粥样硬化呈正相关[OR(95%CI)=1.428(1.065～1.915),P <0.05]，与加权中位数法分析结果一致。在孟德尔随机化分析中高分贝音乐与高血压、心肌梗死、心房颤动以及心力衰竭无关（P> 0.05）。敏感性分析表明研究结果不存在偏倚，工具变量不存在异质性。结论 高分贝音乐与缺血性脑卒中、冠状动脉粥样硬化之间存在正向因果关系，高分贝音乐对其他心血管疾病的因果作用需要进一步研究。更多还原

【Abstract】 Objective This study employed a two-sample Mendelian randomization approach to investigate the causal relationship between high-decibel music exposure and six cardiovascular diseases. Methods From the whole-genome association study database, single nucleotide polymorphisms related to high-decibel music, hypertension, ischemic stroke, coronary artery atherosclerosis, myocardial infarction, atrial fibrillation, and heart failure, were screened as genetic instrumental variables. Three Mendelian randomization analysis methods, including inverse variance-weighted method, MR-Egger method, and weighted median method, were utilized to evaluate the causal relationship between highdecibel music and cardiovascular diseases. Sensitivity analyses were conducted using Cochran’s Q test, MR-Egger regression, MR-PRESSO analysis, and leave-one-out method. Results The inverse variance-weighted method indicated a positive correlation between high-decibel music and ischemic stroke [OR(95%CI)=1.424(1.061-1.911), P < 0.05] as well as coronary artery atherosclerosis [OR(95%CI)=1.428(1.065-1.915), P < 0.05], consistent with the results of the weighted median method.Mendelian randomization analysis revealed no association between high-decibel music and hypertension,myocardial infarction, atrial fibrillation, and heart failure(P > 0.05). Sensitivity analysis demonstrated no bias in the study results, and instrumental variables exhibited no heterogeneity. Conclusion There is a positive causal relationship between high-decibel music and ischemic stroke, as well as coronary artery atherosclerosis. Further research is needed to explore the causal effects of high-decibel music on other cardiovascular diseases.更多还原