【摘要】 目的 探讨梅毒疾病患者实施头孢克肟与苄星青霉素治疗的效果。方法 目的选取南通瑞慈医院2020年1月—2023年12月收治的48例梅毒患者为研究对象，按治疗方法分为对照组与研究组，各24例。对照组予以肌内注射苄星青霉素药物，研究组在对照组治疗基础上联合口服头孢克肟药物，比较两组梅毒患者治疗疗效、临床症状缓解时间及不良反应情况。结果 研究组治疗梅毒患者总有效率为91.67%(22/24），高于对照组的66.67%(16/24），差异有统计学意义（χ~2=4.547,P<0.05）。研究组治疗梅毒患者期间各临床症状缓解时间均短于对照组，差异有统计学意义（P均<0.05）。两组药物治疗期间梅毒患者不良反应总发生率对比，差异无统计学意义（P>0.05）。结论 梅毒患者实施头孢克肟与苄星青霉素联合治疗优于单一治疗疗效，能改善患者免疫功能，用药安全性良好。更多还原

【Abstract】 Objective To explore the therapeutic effect of cefixime and benzathine penicillin in the treatment of syphilis patients.Methods 48 syphilis patients admitted to the Nantong Ruici Hospital from January 2020 to December2023 were objectively selected as study subjects,and were divided into control group and study group according to treatment method,with 24 cases each.The control group was given intramuscular injection of benzathine penicillin,while the study group was combined with oral cefixime on the basis of control group treatment,and the therapeutic efficacy,clinical symptom remission time and adverse reactions of the two groups of syphilis patients were compared.Results The total effective rate of the study group was 91.67%(22/24),higher than 66.67%(16/24) of the control group,the difference was statistically significant (χ~2=4.547,P<0.05);The remission time of clinical symptoms in the study group was shorter than that in the control group,the differences were statistically significant (all P<0.05).There was no statistically significant difference in the total incidence of adverse reactions between the two groups during drug treatment (P>0.05).Conclusion The combined treatment of cefixime and benzathine penicillin in syphilis patients is better than single treatment,which can improve the immune function of patients and the safety of the drug is good.更多还原