【摘要】 目的 探析血清过氧化物酶体增殖物激活受体γ共激活因子1α(PGC-1α)水平与多囊卵巢综合征(PCOS)患者体外受精-胚胎移植(IVF-ET)妊娠结局的关系。方法 选取2021年1月至2022年12月于广西壮族自治区妇幼保健院接受IVF-ET治疗的99例PCOS患者作为研究对象，依据患者妊娠结局分为妊娠组(n=49)和未妊娠组(n=50)。收集并比较所有患者基线资料以及性激素、血清PGC-1α水平等。采用Logistic回归分析影响PCOS患者IVF-ET妊娠结局的危险因素；采用受试者工作特征(ROC)曲线评估血清PGC-1α水平对PCOS患者IVF-ET妊娠结局的预测价值。结果 99例PCOS患者中有49例妊娠成功，妊娠成功率为49.49%。未妊娠组血清甘油三酯(TG)、睾酮(T)水平均高于妊娠组，且血清PGC-1α水平低于妊娠组，差异具有统计学意义(P<0.05)。Logistic回归分析显示，血清T、TG水平高是PCOS患者IVF-ET治疗后妊娠结局的危险因素(OR>1,P<0.05),PGC-1α水平高是PCOS患者IVF-ET治疗后妊娠结局的保护因素(OR<1,P<0.05)。绘制ROC曲线显示，血清PGC-1α水平预测PCOS患者IVF-ET妊娠结局的曲线下面积(AUC)为0.752(95%CI:0.654～0.850,P<0.05),具有一定的预测价值。当血清PGC-1α的Cut-off值为0.485 ng/mL时，预测PCOS患者IVF-ET妊娠结局的灵敏度和特异度分别为76%、67%。结论 血清PGC-1α水平与PCOS患者IVF-ET妊娠结局有关，且当其水平达0.485 ng/mL时，妊娠失败风险明显增加，具有一定的预测价值，未来或可将其作为预测IVF-ET妊娠结局的辅助指标。更多还原

【Abstract】 Objective To explore the relationship between serum peroxisome proliferator-activated receptor γ coactivator 1α(PGC-1α) level and pregnancy outcome of in vitro fertilization and embryo transfer(IVF-ET) in patients with polycystic ovarian syndrome(PCOS). Methods From January 2021 to December 2022, 99 PCOS patients who received IVF-ET treatment in Maternity and Child Health Care of Guangxi were selected as the study subjects. According to the pregnancy outcomes, the patients were divided into pregnancy group(n=49) and non-pregnancy group(n=50). The baseline data of all patients, as well as the levels of sex hormones and serum PGC-1α were collected and compared. Logistic regression analysis was used to analyze the risk factors for IVF-ET pregnancy outcomes in PCOS patients. And the predictive value of serum PGC-1α level on IVF-ET pregnancy outcomes in PCOS patients was evaluated using the receiver operating characteristic(ROC) curve. Results Among the 99 patients with PCOS, 49 cases had successful pregnancies, with a success rate of 49.49%. The serum triglyceride(TG) and testosterone(T) levels in the non-pregnancy group were all higher than those in the pregnancy group, and the serum PGC-1α level was lower than those in the pregnancy group, with statistical significant differences(P<0.05). Logistic regression analysis showed that high serum T and TG levels were risk factors for pregnancy outcome after IVF-ET treatment(OR>1, P<0.05), and high PGC-1α level was a protective factor for pregnancy outcome after IVF-ET treatment in PCOS patients(OR<1, P<0.05). ROC curve was drawn and displayed the area under curve(AUC) of serum PGC-1α level predicting IVF-ET pregnancy outcome in PCOS patients was 0.752(95%CI:0.654-0.850, P<0.05), which had certain predictive value. When the Cut-off value of serum PGC-1α reached 0.485 ng/mL, the sensitivity and specificity of predicting IVF-ET pregnancy outcome in PCOS patients were 76% and 67%, respectively. Conclusions Serum PGC-1α level is related to IVF-ET pregnancy outcome in PCOS patients, and when its level reaches 0.485 ng/mL, the risk of pregnancy failure increases significantly, which has certain predictive value. In the future, it may be used as an auxiliary indicator to predict IVF-ET pregnancy outcome.更多还原