【摘要】 目的 探讨慢性病患者生命质量测量体系之消化性溃疡量表QLICD-PU(V2.0)得分的最小临床重要性差值(MCID)。方法 采用方便抽样，于2013年3月至2014年8月使用QLICD-PU(V2.0)量表进行问卷调查，采用效标法和分布法制定MCID,分析比较取平均值法、取小值法和取大值法制定的MCID。结果 取平均值法得到的生理功能(8.53)、心理功能(8.45)、社会功能(7.61)、共性模块(7.05)、特异模块(8.82)和量表总分(7.53);取小值法得到的MCID分别为5.25、5.78、6.16、4.19、7.18、4.09;取大值法得到的MCID分别为11.99、12.05、10.09、9.48、10.99、11.04。结论 本文采用多种方法和标准制定了MCID,使用者可根据情况选用。MCID可用于评估消化性溃疡患者的临床疗效，为生命质量的应用提供参考。在后续研究中，制定的MCID值可通过临床实践进一步验证。更多还原

【Abstract】 Objective To explore the minimum clinically important difference(MCID) of peptic ulcer scale QLICD-PU(V2.0) among the System of quality of life instruments for chronic diseases.Methods Using convenience sampling, the questionnaire was administered from March 2013 to August 2014 using the QLICD-PU(V2.0) scale, and the MCIDs were calculatedusing the anchor-based and distribution-based methods, respectively, and analyzed to compare the MCIDs developed by taking the mean, taking the minimum, and taking the maximum methods. Results The MCIDs of physical functioning(8.53), psychological functioning(8.45), social functioning(7.61), general module(7.05), specific module(8.82), and overall scale(7.53) obtained by taking the mean method; the MCIDs obtained by taking the minimum method were 5.25, 5.78, 6.16, 4.19, 7.18 and 4.09, respectively; the MCID obtained by taking the maximum method were 11.99, 12.05, 10.09, 9.48, 10.99 and 11.04, respectively. Conclusion In this paper, MCID was formulated by using various methods and criteria, which can be chosen by the users according to the situation. MCID can be used to assess the clinical efficacy of patients with peptic ulcers for the application of quality of life. The MCID values formulated can be validated further by clinical practice in subsequent studies.更多还原