【摘要】 目的 了解河南省耐药结核病患者死亡的相关影响因素。方法 选取河南省全部18个地级市以及2个直管县，2011—2021年期间确诊的结核病患者资料，筛选出具有完整疗程记录及治疗结局的患者，使用Kaplan-Meier法计算患者累积生存率，Cox比例风险回归识别可能影响患者生存时间的因素。结果 1 078例耐药结核病患者中，死亡患者共计66例（6.1%）,30个月内累积生存率为90.1%,50%患者的死亡发生在10个月以内。在控制了其他因素后，年龄（HR=1.053,95%CI:1.029～1.087）、广泛耐药结核病（XDR-TB）(HR=3.032,95%CI:1.584～5.767)、吸烟（HR=1.879,95%CI:1.006～3.509）、BMI(HR=0.294,95%CI:0.088～0.978)是影响结核病患者治疗期间死亡的主要危险因素。结论河南省耐药结核病患者中，老年、XDR-TB、有吸烟习惯以及BMI小于18.5 kg/m2的患者具有相对更高的死亡风险，为这些患者的治疗提供额外的支持以减少患者死亡率。更多还原

【Abstract】 Objective To investigate the related factors of death in patients with drug-resistant tuberculosis in Henan Province. Methods The data of tuberculosis patients diagnosed in all 18 prefecture-level cities and 2 directly administered counties in Henan Province from 2011 to 2021 were selected. The patients with complete course of treatment and treatment outcome were selected. The cumulative survival rate was calculated by Kaplan-Meier method, and Cox proportional hazard regression was used to identify the factors affecting the survival time of patients. Results Among the 1 078 patients with drug-resistant tuberculosis, a total of 66 patients(6.1%) died, and the cumulative survival rate within 30 months was 90.1%.In total 50% of the patients died within 10 months. After controlling other factors, age(HR=1.053, 95%CI: 1.029-1.087),XDR-TB patients(HR=3.032, 95%CI: 1.584-5.767), smoking(HR=1.879, 95%CI: 1.006-3.509) and BMI(HR=0.294, 95%CI: 0.088-0.978) were the main risk factors for death of tuberculosis patients during treatment. Conclusion Among drug-resistant tuberculosis patients in Henan Province, elderly patients, XDR-TB patients, smoking patients and patients with BMI less than 18.5 have a relatively higher risk of death. Additional support should be provided for the treatment of these patients to reduce mortality.更多还原