【摘要】 目的 基于美国国家健康和营养调查数据(NHANES)探讨膳食氧化平衡评分(DOBS)与慢性肾脏病(CKD)患者骨质疏松症患病风险的关系。方法 本研究人群选自NHANES 2007—2008、2009—2010、2013—2014、2017—2018共4个调查周期中40岁及以上CKD患者，采用加权logistic回归评估DOBS与CKD患者骨质疏松症患病风险的关联，采用平滑曲线拟合阐明二者之间的剂量-反应关系，并根据年龄和性别进行亚组分析。结果 共纳入2281例参与者，完全调整模型(模型3)发现，较高的DOBS可显著降低CKD患者骨质疏松症患病风险，与Q1相比，DOBS的最高四分位数组(Q4)的OR值为0.400(95%CI:0.211～0.758)。平滑曲线拟合发现，DOBS与骨质疏松症的患病率呈负向线性剂量-反应关系。亚组分析发现，DOBS与骨质疏松症的负向关联分别在女性和≥65岁CKD患者中更显著。结论 DOBS与CKD患者骨质疏松症患病风险关系呈线性负向相关，并表现出性别与年龄差异，但仍需进一步研究证实。更多还原

【Abstract】 Objective To explored the relationship between the Dietary Oxidative Balance Score(DOBS) and the risk of developing osteoporosis in patients with chronic kidney disease(CKD) based on data from the National Health and Nutrition Examination Survey(NHANES). Methods The study population was selected from CKD patients aged 40 years and above in a total of four survey cycles of NHANES 2007—2008, 2009—2010, 2013—2014, and 2017—2018, and the association between DOBS and the risk of developing osteoporosis in CKD patients was assessed using weighted logistic regression, with smoothed curve fitting demonstrating the dose-response relationship between the two and subgroup analyses based on age and gender. Results A total of 2 281 participants were included in this study, and the fully adjusted model(Model 3) found that higher DOBS significantly reduced the risk of osteoporosis in CKD patients, with an OR of 0.400(95%CI: 0.211-0.758) in the highest quartile group of DOBS(Q4) compared with Q1. Smoothed curve fitting revealed a negative linear dose-response relationship between DOBS and the prevalence of osteoporosis. Subgroup analysis revealed that the negative association between DOBS and osteoporosis was more significant in female and ≥65-year-old CKD patients, respectively. Conclusion In this study, we found that the relationship between DOBS and the risk of osteoporosis in CKD patients was linearly negatively correlated and showed gender and age differences, but further studies are needed to confirm this.更多还原