【摘要】 目的 基于中医体质分析东北地区白癜风患者的相关影响因素及临床预测作用。方法 采用横断面研究，对2022年1月—2024年1月至黑龙江中医药大学附属第一医院就诊的120例白癜风患者(白癜风组)和280例健康体检人员(健康对照组)进行问卷调查及体质判定，比较2组性别、年龄、文化程度、婚姻状况、过敏史、手术史、皮肤病史、家族史、规律饮食情况、中医体质类型，Logistic回归分析东北地区白癜风发病与中医体质等因素的相关性，同时绘制预测模型(ROC)曲线评估中医体质等因素对白癜风患者的预测价值。结果 健康对照组纳入252例，白癜风组纳入120例。2组性别、年龄、文化程度、婚姻状况和手术史比较差异均无统计学意义(P均>0.05);2组过敏史、皮肤病史、家族史、规律饮食情况、部分中医体质类型比较差异均有统计学意义(P均<0.05),寒冷地区白癜风患者体质以偏颇体质为主。多因素Logistic回归显示，过敏史、皮肤病史、家族史、阳虚质、气虚质、气郁质与寒冷地区白癜风发病显著相关(P均<0.05),为影响白癜风患病的危险因素。ROC曲线分析显示，曲线下面积(AUC)为0.731(95%CI:0.678～0.784,P<0.001)。结论 偏颇体质、过敏史、皮肤病史、家族史与寒冷地区白癜风发病存在关联，且具有一定的临床预测价值，临证时可依据相关风险因素对白癜风风险进行预测，通过体质辨识与对应的健康管理，更好地实现白癜风患者的个体化防治。更多还原

【Abstract】 Objective It is to analyze the relevant influencing factors and its clinical predictive values in vitiligo patients in Northeast China based on Chinese medicine constitution. Methods A cross-sectional study was performed, 120 vitiligo patients(vitiligo group) and 280 healthy medical examiners(healthy control group) who visited the First Hospital Affiliated to Heilongjiang University of Traditional Chinese Medicine from January 2022 to January 2024 underwent a questionnaire survey and diagnosis of their constitution, the gender, age, education level, marital status, history of allergy, and history of surgery, history of skin disease, family history, regular diet, and constitution of traditional Chinese medicine were compared between the two groups, the correlations of vitiligo onset with constitution type and other factors were analyzed by Logistic regression analysis, and the ROC curves of the predictive models were drawn to assess the predictive value of constitution types and other factors for vitiligo patients. Results A total of 252 cases were included in the healthy control group and 120 cases were included in the vitiligo group. The differences in gender, age, education level, marital status, and surgical history were not statistically significant between the two groups(all P>0.05), the differences in allergy history, dermatologic history, family history, regular dietary and some constitutions of traditional Chinese medicine were statistically significant between the two groups(all P<0.05), the constitutions of the vitiligo patients in cold regions mainly were biased. Multifactorial logistic regression showed that history of allergy, history of skin disease, family history, Yang deficiency constitution, Qi deficiency constitution and Qi stagnation constitution were significantly associated with the development of vitiligo in cold regions(all P<0.05), they were the risk factors for vitiligo. The ROC curve analysis showed that the area under the ROC curve(AUC) was 0.731(95% CI: 0.678-0.784, P<0.001). Conclusion Biased constitution, allergy history, skin disease history, family history are related with incidence of vitiligo in cold regions, we can predict the risk of vitiligo according to the relevant risk factors in clinic, and achieve individualized prevention and treatment of vitiligo patients more effectively through the identification of the constitution and corresponding health management.更多还原