【摘要】 目的：评估尼莫地平联合丁苯酞治疗缺血性脑卒中后血管性痴呆的临床效果。方法：选取2022年1—12月黑龙江省第二医院收治的100例缺血性脑卒中后血管性痴呆患者作为研究对象，随机分为观察组与对照组，各50例。对照组接受丁苯酞治疗，观察组接受尼莫地平联合丁苯酞治疗。比较两组治疗效果。结果：治疗后，两组简易智力状态检查量表、蒙特利尔认知评估量表评分升高，且观察组高于对照组(P<0.05)。观察组治疗总有效率高于对照组(P<0.05)。治疗后，两组日常生活能力量表评分升高，且观察组高于对照组(P<0.05)。治疗后，两组超氧化物歧化酶水平升高，且观察组高于对照组(P<0.05)。治疗后，两组全血中切黏度、全血高切黏度和全血低切黏度低于治疗前，且观察组低于对照组，差异有统计学意义(P<0.05)。两组不良反应发生率比较，无显著性差异(P>0.05)。结论：尼莫地平联合丁苯酞治疗缺血性脑卒中后血管性痴呆的临床效果显著，能改善患者认知功能、日常生活能力、血流动力学，减轻氧化应激反应，且安全性较高。更多还原

【Abstract】 Objective: To assess the clinical effect of nimodipine combined with butylphthalide in treatment of vascular dementia after ischemic stroke. Methods: A total of 100 patients with vascular dementia after ischemic stroke admitted to the Second Hospital of Heilongjiang Province from January 2022 to December 2022 were selected as the study subjects. They were randomly divided into observation group and control group, with 50 cases in each group. The control group was treated with butylphthalide,and the observation group was treated with nimodipine and butylphthalide. The treatment effects were compared between the two groups. Results: After treatment, the scores of the Mini-Mental State Examination and the Montreal Cognitive Assessment Scale increased in the two groups, and the scores in the observation group were higher than those in the control group(P<0.05). The total effective rate of treatment in the observation group was higher than that in the control group(P<0.05). After treatment, the scores of the daily living ability scale increased in the two groups, and the scores in the observation group were higher than those in the control group(P<0.05). After treatment, the levels of superoxide dismutase increased in the two groups, and the levels in the observation group were higher than those in the control group(P<0.05). After treatment, the whole blood viscosity, whole blood high viscosity and whole blood low viscosity in two groups were lower than those before treatment, and these indexes in the observation group were lower than those in the control group, and the difference was statistically significant(P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05). Conclusion: Nimodipine combined with butylphthalide in the treatment of vascular dementia after ischemic stroke has significant clinical effects, and can improve patients’ cognitive function, daily living ability and hemodynamics, relieve oxidative stress response, and have high safety.更多还原