【摘要】 去泛素化酶家族成员参与调控多种细胞信号转导及代谢过程,其异常表达或活性改变与肿瘤等多种疾病的发展密切相关。肿瘤抑制因子(cylindromatosis, CYLD)在多种肿瘤中低表达,并且是去泛素化酶家族成员之一。它能够去除特定蛋白上的泛素链,对细胞内NF-κB、Wnt、JNK等多种信号通路进行调节,影响细胞的生长、分化和凋亡等过程,其表达异常与多种癌症及遗传性疾病相关。近年来报道了大量有关CYLD在各种肿瘤进展中作用方式的研究,该文对CYLD在主要相关信号通路中的研究及其对肿瘤的影响进行综述。更多还原

【Abstract】 Members of the deubiquitinating enzyme family are involved in the regulation of a variety of cellular signal transduction and metabolic processes, and their aberrant expression or altered activity is closely related to the development of tumors and other diseases. The tumor suppressor CYLD(cylindromatosis) is lowly expressed in a variety of tumors and is a member of the deubiquitinating enzyme family. It can remove the ubiquitin chain on specific proteins, regulate various intracellular signaling pathways such as NF-κB, Wnt, JNK and so on,and affect the processes of cell growth, differentiation and apoptosis, and its aberrant expression has been associated with a variety of cancers and hereditary diseases. In recent years, a large number of studies on the mode of action of CYLD in the progression of various tumors have been reported, and this article provides an overview of the study of CYLD in the main relevant signaling pathways and its effects on tumors.更多还原