【摘要】 细胞自噬是真核生物中一种高度保守的由溶酶体介导的降解过程。自噬小体是在自噬过程中形成的双膜囊泡,用于包裹自噬底物并将其运输到溶酶体进行后续降解,以维持细胞的存活、生长和稳态。自噬是一种维持细胞稳态的重要机制,参与机体生命过程的多个方面,自噬异常与多种人类疾病的发生发展密切相关。因此,对自噬小体生物发生和成熟的机制探究具有重要的意义。该文总结了多细胞真核生物中自噬小体的形成过程,并阐述了自噬小体生物发生和成熟的调控机制,为自噬相关的研究提供参考。更多还原

【Abstract】 Autophagy is an evolutionarily conserved lysosome-mediated degradation process in the cell.Autophagosomes are double-membrane vesicles formed during autophagy to engulf a wide range of cytosolic contents and transport them to lysosomes for subsequent degradation, which therefore have essential roles in survival,development, and homeostasis of the cell. Autophagy plays important roles in the physiological process of different organisms and its disruption has been associated with the pathogenesis of various human diseases. Thus, the exploration to the mechanism of autophagosome biogenesis and maturation has a great significance. Here, this article summarizes the autophagosome formation process and the molecular mechanisms underlying autophagosome maturation in multicellular eukaryotes to provide insights into the studies related to autophagy.更多还原