【摘要】 CRF01＿AE作为HIV最主要的流行重组毒株，在全球范围长时序演变，形成区域间的流行特征，构成特色且独立的流行与传播模式，本文从其起源、遗传多样性、流行特征及其对诊断和治疗延迟、疾病进程、治疗效果影响等方面进行综述，阐释CRF01＿AE及时监测对遏制HIV区域间和全球蔓延的作用。更多还原

【Abstract】 As the most prevalent recombinants of HIV-1 globally, CRF01＿AE plays an increasingly prominent role in HIV-1 long-time viral evolution with regional variation and distinct global distributions and transmissions. This review provides an update on origin, viral variation, epidemiology, impacts on disease progression, timely accessibility of healthcare services, and treatment pertinent to CRF01＿AE. Noticeably, ongoing CRF01＿AE recombination necessitates continued and improved surveillance of HIV-1 molecular epidemiology, which is crucial to curbing the regional HIV-1transmission and achieving the global "End AIDS" target.更多还原