【摘要】 细胞因子在不同自身免疫性疾病中作用可能有所不同，在抗中性粒细胞胞浆抗体(ANCA)相关性血管炎中，不同的细胞因子谱可反映特定器官受累程度；在溃疡性结肠炎(UC)中发病、进展和晚期不同疾病进程中有不同细胞因子谱的水平升高；在青少年特发性关节炎(JIA)中细胞因子风暴参与巨噬细胞激活综合征的发生；在特应性皮炎中细胞因子可通过影响脂质代谢酶导致表皮屏障缺陷；在银屑病中细胞因子又可介导微生物群失衡导致血管生成和慢性炎症。更多还原

【Abstract】 The role of cytokines in different autoimmune diseases may be different. In ANCA-associated vasculitis, different cytokine profiles may reflect the degree of involvement of specific organs. There are increased levels of different cytokine profiles in the onset, progression and advanced stages of ulcerative colitis. Cytokine storm is involved in macrophage activation syndrome in juvenile idiopathic arthritis. In atopic dermatitis, cytokines can cause epidermal barrier defects by influencing lipid metabolizing enzymes. In psoriasis, cytokines also mediate microbiome imbalances that lead to angiogenesis and chronic inflammation.更多还原