【摘要】 目的 掌握北京市东城区饮用水中有机磷酸酯(organophosphate esters, OPEs)及其代谢产物的污染情况，并对成人的饮用水暴露风险进行评估。方法 采用全自动固相萃取-同位素稀释-液相色谱-串联质谱法测定饮用水中14种OPEs及7种有机磷酸酯代谢产物的含量，结合饮用水推荐摄入量，计算日均潜在暴露量(average daily potential dose, ADD)。结果 对17件市政末梢水及30件商超采集的包装饮用水进行测定，饮用水中OPEs及代谢产物磷酸二酯(organophosphate diesters, di-OPEs)被广泛检出，检出率超过50%的OPEs有11种，di-OPEs有6种，ΣOPEs为16.8～177 ng/L,Σdi-OPEs为0.328～16.3 ng/L。成年人群经饮用水的OPEs日均暴露量：男性和女性14种ΣOPEs的ADD分别为3.15和3.10 ng/(kg·BW·d),高暴露量(P95)分别为6.95和7.00 ng/(kg·BW·d);男性和女性7种Σdi-OPEs的ADD分别为0.150和0.147 ng/(kg·BW·d),P95暴露量分别为0.330和0.332 ng/(kg·BW·d)。按照美国国家环境保护局的口服参考剂量评价方式计算通过饮用水暴露OPEs的危险熵，结果远远小于1。结论 东城区居民当前经饮用水的OPEs暴露量对成年居民的健康风险较低，但因代谢产物尚无健康指导值，可能低估暴露风险。更多还原

【Abstract】 OBJECTIVE To investigate the pollution of organophosphate esters(OPEs) and their metabolites in drinking water in Dongcheng District of Beijing, and to assess the exposure risk of adults in drinking water.METHODS The contents of 14 OPEs and 7 metabolites in drinking water were determined by automatic solid phase extraction, isotope dilution and liquid chromatography tandem mass spectrometry. The average daily potential dose(ADD) were calculated based on the recommended intake of drinking water.RESULTS Seventeen pieces of tap water and 30 pieces of packaged drinking water collected by supermarket were measured. OPEs and di-OPEs were widely detected in drinking water(11 kinds of OPEs and 6 kinds of di-OPEs with the detection rate of more than 50%). The ΣOPEs range was 16.8 to 177ng/L, and the Σdi-OPEs range was 0.328 to 16.3 ng/L. The average daily dose of adult population was calculated: the ADD of 14 kinds of ΣOPEs in male and female were 3.15 and 3.10 ng/(kg·BW·d), and the P95 exposure was 6.95 and 7.00 ng/(kg·BW·d), respectively. The ADD of the seven Σdi-OPEs in male and female were 0.150 and 0.147 ng/(kg·BW·d), and the P95 exposure was 0.330 and 0.332 ng/(kg·BW·d), respectively. The hazard quotient(HQ) of exposure to OPEs through drinking water, calculated using the EPA’s oral reference dose assessment, was much less than 1.CONCLUSION The current exposure of OPEs via drinking water poses a low health risk to adult residents in Dongcheng District. However, due to the lack of Health-based guidance values for the metabolites of OPEs, the exposure risk may be underestimated.更多还原