【摘要】 乙型肝炎病毒（hepatitis B virus, HBV） e抗原（hepatitis B e antigen, HBeAg）阳性的慢性HBV感染依次经历非活动性肝炎（non-aggressive hepatitis, NAH）和活动性肝炎（aggressive hepatitis, AH）2个分期，但仍缺乏界定HBeAg阳性NAH与AH的可靠标准。本文根据179例患者的长期随访队列，以自发性HBeAg血清转换作为终点事件，采用Kaplan-Meier生存分析，指定了丙氨酸转氨酶（alanine transaminase, ALT）、HBV表面抗原（hepatitis B surface antigen, HBsAg）和HBV DNA识别HBeAg阳性NAH的功能截断值；在此基础上，评价了ALT串联HBsAg和串联HBV DNA识别HBeAg阳性NAH的性能。结果显示，ALT≤60 IU/L、HBsAg>4.602 log₁₀ IU/mL和HBV DNA>7.477 log₁₀ IU/mL为识别HBeAg阳性NAH的功能截断值。基于功能截断值，ALT串联HBsAg的患者中，病理学分级≤G1和“分级≤G1且分期≤S2”的构成比均为100%,病理学分期≤S1和“分级≤G2且分期≤S1”的构成比均为68.2%;ALT串联HBV DNA的患者中，病理学分级≤G1和“分级≤G1且分期≤S2”的构成比均为86.2%,病理学分期≤S1和“分级≤G2且分期≤S1”的构成比均为69.0%;ALT串联HBsAg识别病理学分级≤G1和“分级≤G1且分期≤S2”的阳性似然比均为+∞,识别病理学分期≤S1和“分级≤G2且分期≤S1”的阳性似然比均为2.034;ALT串联HBV DNA识别病理学分级≤G1和“分级≤G1且分期≤S2”的阳性似然比分别为3.000和3.068,识别病理学分期≤S1和“分级≤G2且分期≤S1”的阳性似然比均为2.106。以上结果提示，ALT串联HBsAg和串联HBV DNA均可有效识别HBeAg阳性NAH;且ALT串联HBsAg识别HBeAg阳性NAH的性能优于ALT串联HBV DNA。更多还原

【Abstract】 Hepatitis B e antigen（HBeAg）-positive chronic hepatitis B virus（HBV） infection undergoes two phases in sequence, termed non-aggressive hepatitis（NAH） and aggressive hepatitis（AH）, respectively. But there is still a lack of perfect standard for defining HBeAg-positive NAH and AH. In this study, based on a long-term follow-up cohort of 179 patients, the functional cutoffs for alanine transaminase（ALT）, hepatitis B surface antigen（HBsAg） and HBV DNA in identifying HBeAg-positive NAH were designated using Kaplan-Meier survival analysis with spontaneous HBeAg seroconversion as the endpoint event; On this basis, the performance of ALT in tandem with HBsAg and in tandem with HBV DNA in identifying HBeAg-positive NAH was evaluated. The results showed that, ALT≤60 IU/L, HBsAg >4.602 log₁₀ IU/mL and HBV DNA >7.477 log₁₀ IU/mL were the functional cutoffs in identifying HBeAg-positive NAH. Based on the functional cutoffs, among patients with ALT in tandem with HBsAg, the proportion of patients with pathological grade≤G1 and “grade≤G1 and stage≤S2” were both 100%, and with pathological stage≤S1 and “grade≤G2 and stage≤S1” were both 68.2%; among patients with ALT in tandem with HBV DNA, the proportion of patients with pathological grade≤G1 and “grade≤G1 and stage≤S2” were both 86.2%, and with pathological stage≤S1 and “grade≤G2 and stage≤S1” were both 69.0%; the positive likelihood ratios of ALT in tandem with HBsAg in identifying pathological grade≤G1 and “grade≤G1 and stage≤S2” were both +∞, and in identifying pathological stage≤S1 and “grade≤G2 and stage≤S1” were both 2.034; the positive likelihood ratios of ALT in tandem with HBV DNA in identifying pathological grade≤G1 and “grade≤G1 and stage≤S2” were 3.000 and 3.068, respectively, and in identifying pathological stage≤S1 and “grade≤G2 and stage≤S1” were both 2.106. The results suggested that, both ALT in tandem with HBsAg and in tandem with HBV DNA can effectively identify HBeAg-positive NAH. The performance of ALT in tandem with HBsAg in identifying HBeAg-positive NAH is better than that of ALT in tandem with HBV DNA.更多还原