【摘要】 基于香豆素荧光团设计合成了一种光热剂(ECEI),其光热转换效率可达85.78%。此外,冷热循环的实验结果表明,ECEI具有良好的光稳定性。即使在线粒体膜电位受损的情况下,ECEI也能有效靶向线粒体,在激光照射下诱导癌细胞死亡。这使ECEI能够最大程度地破坏线粒体,从而抑制肿瘤细胞的繁殖。对小鼠肿瘤照射1次后,小鼠肿瘤在10 d内逐渐消失,这表明ECEI具有良好的肿瘤抑制效果。更多还原

【Abstract】 A photothermal agent(ECEI) with high photothermal conversion efficiency(85.78%) was synthesized based on coumarin fluorescent groups. In addition, the experimental results of hot and cold cycling show that ECEI has good photostability. Despite damage to the mitochondrial membrane potential,ECEI can effectively target mitochondria and induce cancer cell death under laser irradiation. This allows ECEI to maximize mitochondrial damage and thus inhibit tumor cell reproduction. Notable, after irradiating mouse tumors once, the mouse tumors gradually disappeared within 10 d. This indicates that ECEI has an excellent tumor inhibition effect.更多还原