【摘要】 短链脂肪酸（SCFAs）是以膳食纤维为底物的肠道菌群代谢物，可通过影响胃肠激素、肠神经系统、平滑肌细胞、Cajal间质细胞（ICC）等多种机制参与肠道动力的调节。肠道动力障碍性疾病患者肠道内SCFAs浓度发生变化，通过补充SCFAs制剂、高纤维饮食、益生菌/益生元和粪菌移植（FMT）可以改善患者症状。本文就SCFAs对肠道动力的作用及其机制研究进展作一综述。更多还原

【Abstract】 Short-chain fatty acids(SCFAs) are metabolites of intestinal microbiota produced from dietary fiber fermentation. They regulate the intestinal motility through multiple mechanisms including modulation of gastrointestinal hormones, enteric nervous system, smooth muscle cells and interstitial cells of Cajal(ICC). Alterations in SCFAs concentration have been observed in patients with intestinal motility disorders. Therapeutic interventions such as SCFAs supplementation, high-fiber diets, probiotics/prebiotics, and fecal microbiota transplantation(FMT) have demonstrated efficacy in improving clinical symptoms. This article reviewed research progress on the roles and mechanisms of SCFAs in intestinal motility.更多还原