【摘要】 目的 探究重复经颅磁刺激（repetitive transcranial magnetic stimulation,rTMS）联合综合康复干预对孤独症谱系障碍（autism spectrum disorder,ASD）患儿临床症状及语言功能康复的影响。方法 选取2021年8月～2023年5月在湖南省儿童医院康复中心接受治疗的141例ASD儿童，采用随机数表法分为观察组（72例）和对照组（69例）。对照组患儿给予常规综合康复治疗，观察组患儿在对照组基础上给予rTMS治疗，并对所有患儿进行5个月跟踪随访。对比相关参数及量表评分。结果 治疗后，观察组孤独症行为量表（autism behavior checklist,ABC）和儿童孤独症评定量表（childhood autism rating scale,CARS）评分均显著低于对照组（P<0.05），对比0～6岁小儿神经心理发育检查表得分，观察组治疗后适应能力、社交能力及语言功能得分均显著高于对照组（P<0.05），两组粗大动作、精细动作得分无显著差异（P>0.05）。末次随访时，观察组患儿的言语行为里程碑评估和安置计划（verbal behavior milestones assessment and placement program,VB-MAPP）得分显著高于对照组（P<0.05）。结论 r TMS联合综合康复干预可显著改善ASD症状，提高患儿神经、语言、社交及感知等能力。更多还原

【Abstract】 Objective To explore the effects of repetitive transcranial magnetic stimulation(rTMS) combined with comprehensive rehabilitation intervention on clinical symptoms and speech function rehabilitation of children with autism spectrum disorder(ASD).Methods From August 2021 to May 2023, 141 children with ASD were randomly selected in the Rehabilitation Center of Hunan Children’s Hospital and divided into the observation group(72 cases) and the control group(69 cases) by the random number table method. The control group was given conventional comprehensive rehabilitation treatment, and the observation group was given rTMS treatment on the basis of the control group. The relevant parameters and scale scores were compared. All children were followed up for at least 5 months. Results After treatment, Autism Behavior Checklist(ABC) and Childhood Autism Rating Scale(CARS) scores in the observation group were significantly lower than those in the control group(P<0.05). The scores of various factors in the neuropsychological development checklist of children aged 0 to 6 years old showed that adaptive ability, social ability and speech function scores in the observation group were significantly higher than those in the control group after treatment(P<0.05),while there was no difference in gross motor and fine motor scores between the two groups(P>0.05). At the last follow-up, the Verbal Behavior Milestones Assessment and Placement Program(VB-MAPP) scores in the observation group were significantly higher than those in the control group(P<0.05). Conclusions rTMS combined with comprehensive rehabilitation intervention can significantly improve the symptoms of children with ASD, improve their neurological, verbal, social and perceptual abilities.更多还原