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中药药效物质及靶点发现新技术的研究进展

Research progress of new technologies for the discovery of pharmacodynamic substances and targets in Chinese medicines

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【作者】 赵露张舒静王毅

【Author】 ZHAO Lu;ZHANG Shujing;WANG Yi;Institute of Traditional Chinese Medicine,Tianjin University of Traditional Chinese Medicine;Department of Chinese Medicine Science and Engineering,College of Pharmaceutical Science,Zhejiang University;State Key Laboratory of Component-based Chinese Medicine;

【通讯作者】 王毅;

【机构】 天津中医药大学中医药研究院浙江大学药学院中药科学与工程学系组分中药国家重点实验室

【摘要】 科学技术的不断进步推动了中医药现代化研究的进程。然而,在复杂的中药体系中,药效物质难以辨识、作用靶标表征困难等瓶颈问题仍然存在。因此,文章旨在整合近年来中药药效物质筛选及药效靶点发现领域的新技术,以期能够为药效物质发现和药理机制探究提供新的参考,为进一步加快中药现代化进程提供新的见解。

【Abstract】 The continuous advancement of science and technology has facilitated the modernization research of traditional Chinese medicine. However,within the complex system of traditional Chinese medicine,the challenges such as the difficulty in identifying pharmacodynamic substances and targets still exist. Therefore,the aim of this paper is to integrate the new technologies in the fields of pharmacodynamic substance screening and pharmacodynamic target discovery of traditional Chinese medicine in recent years,in order to provide new references for the discovery.

【基金】 浙江省“尖兵“”领雁”研发攻关计划项目(2023C03004);浙江省自然科学基金资助项目(LQ24H280012)
  • 【文献出处】 天津中医药 ,Tianjin Journal of Traditional Chinese Medicine , 编辑部邮箱 ,2024年10期
  • 【分类号】R285
  • 【下载频次】144
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