【摘要】 钛合金骨植入物在骨科临床中得到了越来越广泛的应用，但其较高的弹性模量、较差的抑菌性能及固有的生物惰性等易造成应力遮挡、术后感染以及松动等问题，从而对术后恢复造成较大负面影响．针对这些问题，本研究以3D打印技术获得的力学性能优异的多孔Ti-6Al-4V合金骨植入材料为研究对象，通过阳极氧化工艺在植入物材料表面制得TiO₂微纳结构活性层，并通过光还原的方法负载纳米银颗粒，在对其进行结构优化的基础上深入探讨其结构与亲水性、耐蚀性、抑菌性之间的关系．研究结果表明：3D打印多孔钛合金通过两次阳极氧化可在其表面生成规整TiO₂微纳结构活性层，显著提高了骨植入材料的生物活性和在模拟体液中的耐蚀性，负载微量的Ag纳米颗粒后亲水性变化不大，但抑制大肠杆菌和金黄色葡萄球菌黏附和增值的效果显著．本研究对3D打印生物医用多孔钛合金骨植入物的开发与实际应用提供了重要参考．更多还原

【Abstract】 Utilization of titanium-alloy bone implants in orthopedic clinics has witnessed a significant increase;however,their high elastic modulus,inadequate antibacterial performance,and inherent biological inertness can lead to issues such as stress shielding,postoperative infection,and implant loosening. These issues have a substantial negative impact on the patients’ postoperative recovery. To address these issues,this study investigated a porous Ti-6Al-4V-alloy bone implant material,which was fabricated using three-dimensional（3D）printing technology and possessed exceptional mechanical properties. An anodic oxidation process was used to create a TiO₂ microstructurednanostructured active layer on the implant surface. Additionally,silver nanoparticles were loaded using a photoreduction method. By optimizing its structure,we explored the correlation between hydrophilicity,corrosion resistance,and bacteriostatic properties. Results show that the 3D-printed porous titanium alloy generates a regular TiO₂ microstructured-nanostructured active layer on its surface through two anodizing processes. This layer can considerably enhance the biological activity and corrosion resistance of bone implant materials in simulated body fluids. After loading trace amounts of silver nanoparticles,the hydrophilicity changed marginally. However,this loading played a crucial role in inhibiting the growth and adherence of E. coli and S. aureus. This study provides an important reference for the development and application of 3D-printed biomedical porous titanium-alloy bone implants.更多还原