【摘要】 目的：探讨一种新型黏膜下填充剂辅助上消化道内镜黏膜下剥离术(ESD)的可行性。方法：7例实验家猪采用双盲自身对照研究方法，在同一例实验家猪的食管和胃分别开展ESD，对照组使用0.9 %氯化钠注射液进行黏膜下注射，实验组则使用新型黏膜下填充剂进行黏膜下注射，术后饲养1个月后以内镜评估食管、胃创面愈合情况，之后解剖食管和胃创面进行病理评估。主要观察与比较两组创面的单位面积手术时间，并发症及创面愈合情况。结果：两组实验家猪的胃单位面积手术时间比较，差异均无统计学意义(P>0.05)；实验组的食管单位面积手术时间明显短于对照组，差异具有统计学意义(P<0.05)；术后1个月复查，两组实验家猪出现术后并发症各2例，差异无统计学意义(P>0.05)；创面愈合分级比较，差异均无统计学意义(P>0.05)。结论：该新型黏膜下填充剂可加快食管ESD手术进程，缩短手术时间，且不增加并发症发生率，不影响创面愈合，但没有提高胃ESD速度。更多还原

【Abstract】 Objective To explore the feasibility of a novel submucosal filling agent as an adjunct to endoscopic submucosal dissection (ESD) in the upper gastrointestinal tract.Methods A double-blind,self-controlled study was conducted on7 experimental pigs.ESD was performed on both the esophagus and stomach of each pig.The control group received submucosal injection of 0.9% sodium chloride solution,while the experimental group received the novel submucosal filling agent.After the surgery,the pigs were reared for one month,and then endoscopic evaluation was conducted to assess the healing of the esophageal and gastric wounds.Subsequently,the esophageal and gastric wounds were dissected for pathological evaluation.The primary outcomes observed and compared between the two groups included operation time per unit area of the wound,complications,and wound healing.Results There was no statistically significant difference in the operation time per unit area of the gastric wounds between the two groups (P > 0.05).The operation time per unit area of the esophageal wounds in the experimental group was significantly shorter than that in the control group,with a statistically significant difference (P < 0.05).At the one-month follow-up,2 cases of postoperative complications were observed in both groups,with no statistically significant difference (P > 0.05).There was no statistically significant difference in the wound healing grade between the two groups (P > 0.05).Conclusion The novel submucosal filling agent can accelerate the ESD procedure for the esophagus,shorten the operation time,and does not increase the incidence of complications or affect wound healing.However,it does not improve the speed of ESD for the stomach.更多还原