【摘要】 目的：评价固本清肺方联合西医常规治疗西医诊断为病毒性肺炎、中医诊断为疫病(正气亏虚，湿热毒邪证)患者的有效性和安全性。方法：采用前瞻性单臂试验研究，纳入2023年1月20日至2024年1月15日深圳市中医院收治的100例西医诊断为病毒性肺炎、中医诊断为疫病(正气亏虚，湿热毒邪证)的患者，在西医常规治疗的基础上加用固本清肺方治疗5 d。观察并比较治疗前后患者的主要症状中医证候积分及实验室检验指标。结果：100例患者经固本清肺方联合西医常规治疗后住院时间为8(7,11)d，未出现不良事件，无死亡病例；主要症状发热、咳嗽、乏力、痰量、呼吸困难中医证候积分均较治疗前下降；白细胞计数、C反应蛋白、红细胞沉降率、降钙素原、白细胞介素–6均较治疗前下降且淋巴细胞计数较治疗前升高，差异均具有统计学意义(P<0.05)。结论：本研究发现，对于西医诊断为病毒性肺炎且中医诊断为疫病(正气亏虚，湿热毒邪证)的患者，固本清肺方联合西医常规治疗可以有效缓解患者主要临床症状、改善实验室检验指标，且安全性较好。更多还原

【Abstract】 Objective To evaluate the efficacy and safety of Guben Qingfei Prescription combined with conventional Western medicine in the treatment of patients diagnosed with viral pneumonia by Western medicine and epidemic disease (deficiency of vital qi,damp-heat toxic syndrome) by Traditional Chinese Medicine (TCM).Methods A prospective single-arm trial study was conducted,including 100 patients diagnosed with viral pneumonia by Western medicine and epidemic disease (deficiency of vital qi,damp-heat toxic syndrome) by TCM,who were admitted to Shenzhen Hospital of Traditional Chinese Medicine from January 20,2023,to January 15,2024.On the basis of conventional Western medicine treatment,Guben Qingfei Prescription was added for 5 days.The main symptoms TCM syndrome scores and laboratory test indicators were observed and compared before and after treatment.Results After treatment with Guben Qingfei Prescription combined with conventional Western medicine,the hospital stay of the 100 patients was 8 (7,11) days,with no adverse events or deaths;the TCM syndrome scores for main symptoms such as fever,cough,fatigue,sputum volume,and dyspnea were all lower than those before treatment;white blood cell count,C-reactive protein,erythrocyte sedimentation rate,procalcitonin,and interleukin-6 were all lower than that before treatment,while lymphocyte count was higher than that before treatment,with statistically significant differences (P < 0.05).Conclusion This study found that for patients diagnosed with viral pneumonia by Western medicine and epidemic disease (deficiency of vital qi,damp-heat toxic syndrome) by TCM,Guben Qingfei Prescription combined with conventional Western medicine can effectively alleviate the main clinical symptoms and improve laboratory test indicators with good safety.更多还原