【摘要】 紫云英苷是一种天然的类黄酮，以抗肿瘤等多样化的药理应用而闻名。研究发现紫云英苷具有巨大的抗肿瘤潜力，通过调节PI3K/Akt信号通路、MAPKs信号通路、JAK/STAT信号通路、NF-κB信号通路、Notch1通路、microRNA的表达、肿瘤侵袭和转移等诱导肿瘤细胞凋亡，抑制肿瘤的增殖、侵袭和迁移。本文综述了近年来紫云英苷有关抗肿瘤信号通路的文献报道，分析并总结了每一条通路诱导肿瘤细胞凋亡的可能机制，以期为紫云英苷在抗肿瘤信号通路的开发和利用提供实验和理论依据。更多还原

【Abstract】 Astragalin is a natural flavonoid, which is known for its diverse pharmacological applications such as anti-tumor.The many studies have found that Astragalin has great anti-tumor potential by regulating PI3K/Akt signal pathway, MAPKs signal pathway, JAK/STAT signal pathway, NF-κ B signal pathway, Notch1 pathway, microRNA expression, tumor invasion and metastasis.This article reviews the literature reports on anti-tumor signal pathway of Astragalin in recent years, analyzes and summarizes the possible mechanisms by which each pathway induces tumor cell apoptosis, in order to provide experimental and theoretical basis for the development and utilization of Astragalin in anti-tumor signal pathways.更多还原