【摘要】 目的 观察心脉隆注射液对脓毒症休克患者微循环的影响，以了解心脉隆对脓毒症休克患者中的应用效果与价值。方法 选取本院重症监护室诊治的82例脓毒症休克患者为研究对象，随机分为两组，对照组的41例患者进行常规脓毒症休克集束化治疗，治疗组的41例患者在对照组集束化治疗的基础上加心脉隆注射液，比较两组治疗前、治疗后的血流动力学参数（HR、CVP、CO、MAP、SVR）、血流变（全血还原黏度、血细胞比容、纤维蛋白原、血小板聚集率）、微循环灌注指标（氧合指数、血乳酸水平、SCVO₂、Pcv-aCO₂）及28 d生存率。结果 治疗前两组血流动力学参数、血流变及微循环灌注指标，差异均无统计学意义（P> 0.05）；而治疗后两组的上述方面检测结果均显著改善，且治疗组的检测结果显著地好于对照组，28 d生存率亦优于对照组，差异均有统计学意义（P <0.05）。结论 心脉隆注射液可显著地改善脓毒症休患者的血流动力学参数，改善血流变及微循环灌注指标，提高28 d生存率。在脓毒症休克患者治疗中具有积极的临床治疗效果。更多还原

【Abstract】 Objective To observe the effect of Xinmailong injection on microcirculation in patients with septic shock, so as to understand the application effect and value of Xinmailong injection in patients with septic shock. Methods A total of 82 patients with septic shock treated in the intensive care unit of our hospital were selected as the research objects and randomly divided into two groups. 41 patients in the control group were treated with conventional septic shock cluster therapy, and 41 patients in the treatment group were treated with Xinmailong injection on the basis of cluster therapy in the control group. Then hemodynamic parameters（HR, CVP, CO, MAP, SVR）, hemorheology（whole blood reducing viscosity, hematocrit, fibrinogen, platelet aggregation rate）, microcirculation perfusion indexes（oxygenation index, blood lactate level, SCVO₂, Pcv-aCO₂） and 28-day survival rate were detected and compared between the two groups before and after treatment. Results Before treatment, there were no significant differences in hemodynamic parameters, blood rheology and microcirculation perfusion indexes between the two groups（P > 0.05）. After treatment, the above test results of the two groups were significantly improved, and the test results of the treatment group were significantly better than those of the control group, and the 28-day survival rate was also better than that of the control group. The differences were statistically significant（P < 0.05）. Conclusion Xinmailong injection can significantly improve the hemodynamic parameters, blood rheology and microcirculation perfusion indexes, and improve the 28-day survival rate of patients with sepsis.It has a positive clinical effect in the treatment of septic shock patients.更多还原