【摘要】 目的 分析血栓弹力图指标和D-二聚体与脑胶质瘤患者恶性程度及预后的关系。方法 选取2018年10月—2023年10月重庆市中医院收治的118例脑胶质瘤患者作为研究组，根据恶性程度将其分为低度亚组(WHO分级Ⅰ级～Ⅱ级，n=35)、中度亚组(WHO分级Ⅲ级，n=38)、高度亚组(WHO分级Ⅳ级，n=45)；另选取同期重庆市中医院体检健康者50例作为对照组。比较对照组与研究组、不同恶性程度脑胶质瘤患者、不同预后患者血栓弹力图指标〔凝血综合指数(CI)、最大血凝块强度(MA)、MA后30 min剩余血凝块溶解百分比(CL30)、血细胞凝集块形成速率(α角)、凝血反应时间(R)〕和D-二聚体。结果 研究组CI、MA、α角和D-二聚体高于对照组，CL30低于对照组(P<0.05)。中度亚组CL30低于低度亚组，α角、D-二聚体高于低度亚组(P<0.05)；高度亚组CI、MA、α角、D-二聚体高于低度亚组、中度亚组，CL30低于低度亚组、中度亚组(P<0.05)。随访6个月，存活患者83例，死亡患者35例。死亡患者CI、MA、α角、D-二聚体高于存活患者，CL30、R低于存活患者(P<0.05)。结论 CI、MA、α角、CL30及D-二聚体与脑胶质瘤恶性程度相关，CI、MA、CL30、α角、R及D-二聚体与脑胶质瘤患者预后相关。更多还原

【Abstract】 Objective To analyze the relationship between thrombelastogram index and D-dimer and malignant degree and prognosis of glioma patients.Methods A total of 118 patients with glioma admitted to Chongqing Hospital of Traditional Chinese Medicine from October 2018 to October 2023 were selected as the study group.According to the degree of malignancy,they were divided into low subgroup (WHO grade wasⅠ-Ⅱ,n=35),moderate subgroup (WHO grade was Ⅲ,n=38),and high subgroup (WHO grade was Ⅳ,n=45).Fifety healthy people who underwent physical examination in Chongqing Hospital of Traditional Chinese Medicine during the same period were selected as the control group.The thrombelastogram indexes[coagulation comprehensive index (CI),maximum blood clot strength (MA),residual blood clot dissolution percentage at 30 min after MA (CL30),rate of forming blood cell clot (α angle),coagulation reaction time (R)]and D-dimer were compared between the control group and the study group,patients with different malignant degrees of glioma,and patients with different prognosis.Results CI,MA,αangle and D-dimer in the study group were higher than those in the control group,and CL30 was lower than that in the control group (P < 0.05).The CL30 in the moderate subgroup was lower than that in the low subgroup,and the αangle and D-dimer were higher than those in the low subgroup (P < 0.05).The CI,MA,α angle and D-dimer in the high subgroup were higher than those in the low subgroup and the moderate subgroup,and the CL30 was lower than that in the low subgroup and the moderate subgroup (P < 0.05).Followed up for 6 months,there were 83 cases survived patients,and 35 cases dead patient.CI,MA,αangle and D-dimer in death patients were higher than those in survival patients,while CL30 and R were lower than those in survival patients (P < 0.05).Conclusion CI,MA,α angle,CL30 and D-dimer are related to the malignant degree of glioma.CI,MA,CL30,αangle,R and D-dimer are related to the prognosis of patients with glioma.更多还原