【摘要】 间充质干细胞是多能基质细胞，具有分化成多种细胞的潜力，主要通过其分泌产物——外泌体(EXO)发挥抗凋亡、抗炎、调控自噬及促进内皮细胞和血管生成等作用。研究表明，自噬是一种细胞分解代谢过程，其可维持细胞稳态和存活，修复受损的心肌细胞。本文主要综述了间充质干细胞来源的外泌体(MSCs-EXO)通过调控自噬参与心血管疾病的研究现状，以期为心血管疾病的治疗提供新思路。更多还原

【Abstract】 Mesenchymal stem cells are pluripotent stromal cells that have the potential to differentiate into a variety of cells.They mainly exert anti-apoptotic,anti-inflammatory,regulating autophagy and promoting endothelial cells and angiogenesis by secreting exosomes (EXO).Studies have shown that autophagy is a process of cell catabolism,which can maintain cell homeostasis and survival,and repair damaged cardiomyocytes.This article mainly reviews the research status of mesenchymal stem cell-derived exosomes (MSCs-EXO) involved in cardiovascular diseases by regulating autophagy,in order to provide new ideas for the treatment of cardiovascular diseases.更多还原