【摘要】 自噬是一种保守的溶酶体降解途径，能够降解和回收长寿蛋白或错误折叠的蛋白质和受损的细胞器，以维持细胞的能量和功能。脑血管内皮细胞是神经血管单元（NVU）的重要组成部分，其紧密连接结构是血脑屏障（BBB）的主要结构，而BBB完整性是维持中枢神经系统（CNS）稳态的保障。缺血性脑卒中（CIS）发生时，多种脑内细胞自噬可被激活，包括脑血管内皮细胞、神经元、小胶质细胞和星形胶质细胞等，其中脑血管内皮细胞自噬可影响BBB完整性、细胞凋亡和炎症反应。研究发现，脑血管内皮细胞自噬的激活或抑制可能与沉默信息调节因子1(SIRT-1)/叉头蛋白O3a(FOXO3a)、磷酸肌醇3-激酶（PI3K）/蛋白激酶B(Akt)/雷帕霉素机械靶蛋白（mTOR）、核因子κB(NF-κB)等信号通路有关，且调控脑血管内皮细胞自噬可降低细胞凋亡率、减轻炎症反应和保护BBB的完整性，从而减轻脑缺血缺氧和再灌注损伤。本文从CIS病理过程、脑血管内皮细胞自噬及其发生机制、脑血管内皮细胞自噬在CIS病理过程中的作用进行了综述，认为调控脑血管内皮细胞自噬可能是治疗CIS的一种潜在有效方法。更多还原

【Abstract】 Autophagy is a conserved lysosomal degradation pathway that can degrade and recover long-lived or misfolded proteins and damaged organelles to maintain cellular energy and function. Cerebral vascular endothelial cells are an important part of the neurovascular unit(NVU), and their tightly connected structure is the main structure of the blood-brain barrier(BBB), and the integrity of BBB is the guarantee of maintaining the homeostasis of the central nervous system(CNS).When cerebral ischemic stroke(CIS) occurs, autophagy can be activated in a variety of brain cells, including cerebral vascular endothelial cells, neurons, microglia and astrocytes, among which cerebral vascular endothelial autophagy can affect BBB integrity,apoptosis and inflammation. Studies have shown that the activation or inhibition of autophagy in cerebral vascular endothelial cells may be related to silence information regulator 1(SIRT-1)/forkhead box protein O3a(FOXO3a), phosphoinositide 3-kinase(PI3K)/protein kinase B(Akt)/mechanistic target of rapamycin(mTOR), nuclear factor kappa-B(NF-κB) and other signaling pathways, and regulation of cerebral vascular endothelial autophagy can reduce the apoptosis rate, reduce inflammation and protect the integrity of BBB, thereby reducing cerebral ischemia, hypoxia and reperfusion injury. This article reviewed the pathological process of CIS, autophagy of cerebral vascular endothelial cells and its pathogenesis, and the role of cerebral vascular endothelial autophagy in the pathological process of CIS, and concluded that regulation of cerebral vascular endothelial autophagy may be a potential effective method for the treatment of CIS.更多还原