【摘要】 目的 探讨介入治疗对乳腺癌术后多发转移的治疗效果。方法 对15例乳腺癌术后多发转移患者进行介入治疗。经综合评估后,所有患者实施化疗栓塞治疗,方案为载药微球(DEB)加载多西他赛,联合卡铂,1 d 1次,共21 d,治疗2次,后更改方案为多西他赛+卡铂,联合普通栓塞微球治疗,1 d 1次,共21 d,治疗4次,每2个周期及介入治疗后1、3、6个月行CT/MRI检查,评价其疗效,同时记录不良反应。结果 治疗后3个月总缓解率(ORR)为75%,疾病控制率(DCR)为91.7%;治疗后6个月ORR为50%,DCR为83.3%;常见不良反应大部分在Ⅲ级以下。结论 乳腺癌术后多发转移的介入治疗近期疗效确切,毒副作用小,在乳腺癌术后转移综合治疗中值得进一步推广。更多还原

【Abstract】 Objective To investigate the curative effect of interventional therapy on postoperative multiple metastases of breast cancer.Methods A total of 15 patients with multiple metastases after breast cancer surgery were treated with interventional therapy.After comprehensive evaluation,all patients were treated with chemoembolization.The therapeutic regimen was docetaxel loaded on drug-eluting bead(DEB) combined with carboplatin,once in 1 d for 21 d,2 times in total,and then the regimen was changed to docetaxel and carboplatin combined with ordinary embolization microspheres,once in 1 d for 21 d,4 times in total.CT/MRI was performed on every 2 cycles and 1,3,and 6 months after interventional therapy to evaluate its efficacy and record adverse reactions.Results The overall remission rate(ORR) at 3 months after treatment was 75%,and the disease control rate(DCR) was 91.7%.The ORR and DCR at6 months after treatment were 50% and 83.3%,respectively.Most of the common adverse reactions were below grade Ⅲ.Conclusion Interventional therapy for multiple metastases of breast cancer after operation has a definite short-term effect,with little adverse reactions.It is worthy of further promotion in the comprehensive treatment of postoperative metastases of breast cancer.更多还原