【摘要】 目的 探讨绝经后女性膝骨性关节炎(KOA)患者胫骨平台内翻与骨质疏松(OP)的相关性。方法 回顾性分析接受膝关节单髁置换术的绝经后女性KOA患者194例。收集并分析与胫骨平台内翻[胫骨平台内侧角(MTPA)<85°]相关的危险因素,包括年龄、体质量指数(BMI)、凯格伦-劳伦斯(K-L)分级、髋膝踝角(HKAA)、股骨远端外侧角(LDFA)及骨密度(BMD)。采用多元回归分析这些因素与胫骨平台内翻的关系。采用Pearson相关分析MTPA与BMD的相关性。结果 采用多元线性回归分析结果显示,BMD(β=0.381,P<0.001)及HKAA(β=0.460,P<0.001)是胫骨平台内翻的独立危险因素。LDFA、年龄、BMI、K-L分级与胫骨平台内翻无明显相关性。Pearson相关分析显示BMD与胫骨平台内翻显著相关(r=0.817,P<0.001),对于膝关节内翻(HKAA<175°)的患者,BMD与胫骨平台内翻显著相关(r=0.781,P<0.001)。对于下肢力线正常(HKAA≥175°)的患者,BMD与胫骨平台内翻之间无显著相关(r=-0.035,P=0.063)。结论OP及膝关节内翻是绝经后女性KOA患者膝关节胫骨平台内翻的主要危险因素。更多还原

【Abstract】 Objective To investigate the correlation between tibial plateau varus and osteoporosis(OP) in postmenopausal women with knee osteoarthritis(KOA).Methods A retrospective analysis was conducted on 194 postmenopausal women with KOA who underwent unicompartmental knee arthroplasty.Various risk factors associated with tibial plateau varus [medial tibial plateau angle(MTPA)<85°],including age,body mass index(BMI),Kellgren-Lawrence(K-L)grade,hip-knee-ankle angle(HKAA),lateral distal femur angle(LDFA),bone mineral density(BMD) were collected and analyzed.Multiple regression was employed to analyze the relationship of these factors with tibial plateau varus.Pearson’ s correlation coefficient was used to assess the association between MTPA and BMD.Results Multiple linear regression analysis revealed that BMD(β=0.381,P <0.001) and HKAA(β=0.460,P <0.001)were independent risk factors for tibial plateau varus.LDFA,age,BMI,K-L grade were not significantly associated with tibial plateau varus.A statistically significant association between BMD and tibial plateau varus was noted(r=0.817,P<0.001).Further data stratification showed a significant association between BMD and tibial plateau varus in patients with knee varus(HKAA<175°)(r=0.781,P<0.001).There was no statistical significance association between BMD and tibial plateau varus in patients with normal lower extremity alignment(HKAA≥175°)(r=-0.035,P=0.063).Conclusion OP and knee varus emerge as the primary risk factors for tibial plateau varus in the knee in postmenopausal women with KOA.更多还原