【摘要】 目的 利用Meta分析探讨基于Pfirrmann分级腰椎间盘退变(IVDD)过程中T1ρ值的变化规律。方法 检索自建库至2022年12月20日采用T1ρ成像技术定量评估IVDD的文献,英文数据库检索PubMed、EMBASE、Cochrane Library,中文数据库检索中国知网、万方数据、维普、Sinomed。采用RevMan 5.4和Stata 14.0软件进行Meta分析。结果 共纳入12项研究,纳入PfirrmannⅠ～Ⅴ级腰椎间盘的个数分别为316个、1 460个、769个、430个、98个。随着退变等级增加,腰椎间盘T1ρ弛豫时间均呈逐渐下降的趋势。Ⅰ级腰椎间盘T1ρ值明显高于Ⅱ级[加权均数差(WMD)=14.55,95%置信区间(CI)6.35～22.75,P<0.01],Ⅱ级腰椎间盘T1ρ值显著高于Ⅲ级(WMD=34.20,95%CI 27.05～41.34,P<0.01),Ⅲ级腰椎间盘T1ρ值显著高于Ⅳ级(WMD=22.94,95%CI 17.08～28.80,P<0.01),Ⅳ级腰椎间盘T1ρ值高于V级(WMD=9.35,95%CI 6.81～11.89,P<0.01)。结论 T1ρ成像技术可客观定量评价不同退变时期的椎间盘,尤其对早中期IVDD敏感,可以为临床诊断早期IVDD提供影像学依据。更多还原

【Abstract】 Objective To investigate the change rule of T1ρ value in the process of lumbar intervertebral disc degeneration(IVDD)based on Pfirrmann grading by Meta-analysis.Methods PubMed,EMBASE,Cochrane Library,CNKI,Wanfang Data,VIP and Sinomed were searched to collect studies on quantitative assessment of IVDD using T1ρ imaging technology.The retrieval time limit was from the establishment of the database to December 20,2022.Meta-analysis was performed using RevMan 5.4 and Stata 14.0 software.Results A total of 12 articles were included,and the numbers of Pfirrmann grade Ⅰ-Ⅴ lumbar discs were 316,1 460,769,430 and 98,respectively.T1ρ relaxation time decreased gradually with the increase of the grade of degeneration.The T1ρ values of grade Ⅰlumbar discs were significantly higher than those of grade Ⅱ lumbar discs[weighted mean difference(WMD)=14.55.95% confidence interval(CI) 6.35-22.75,P<0.01],and the T1ρ values of grade Ⅱ lumbar discs were significantly higher than those of grade Ⅲ lumbar discs(WMD=34.20,95 % CI 27.05-41.34,P<0.01).The T1ρ values of grade Ⅲ lumbar discs were significantly higher than that of grade Ⅳ lumbar discs(WMD=22.94,95%CI 17.08-28. 80,P<0.01).The T1ρ values of grade Ⅳ lumbar discs were significantly higher than that of grade V lumbar discs(WMD=9.35,95%CI 6.81-11.89,P<0.01).Conclusion T1ρ imaging technology can objectively and quantitatively evaluate degeneration at different stages,especially sensitive to IVDD in the early and middle stages,which can provide imaging evidence for clinical diagnosis of early IVDD.更多还原