【摘要】 目的 评估定量MRI技术T₂ mapping及mDixon Quant在早期椎间盘退变诊断中的潜在临床价值。方法 使用3.0T MR对79例行腰椎MRI检查的患者进行T2WI、T₂ mapping、mDixon Quant成像,同时记录患者腰痛情况。统计分析分级为PfirrmannⅠ级和PfirrmannⅡ级的椎间盘（其中Ⅰ级76个,Ⅱ级87个）椎体（V）、髓核（NP）的脂肪分数（FF）值、T₂ mapping（map）值的差异。对有意义的参数进行受试者工作特征（ROC）曲线分析。结果 V-FF与椎间盘退行性病变呈轻度正相关,NP-FF和NP-map值与病变呈轻度负相关。在2组之间,V-FF（P<0.001）、NP-FF（P=0.005）和NP-map（P<0.001）统计学差异显著;不同节段椎间盘分别比较时,部分测量值存在统计学差异。结论 V-FF、NP-FF和NP-map与椎间盘退变存在联系,T₂ mapping及mDixon Quant具有潜在的价值,可以定量地评估早期椎间盘退变并帮助诊断。更多还原

【Abstract】 Objective To evaluate the potential clinical value of T2 mapping and mDixon Quant in the diagnosis of early intervertebral disc degeneration.Methods A total of 79 volunteers who underwent lumbar MRI examination were enrolled.All subjects were examined for 3.0T MR with T2 WI,T2 mapping,and mDixon Quant while recording the condition of low back pain.The differences between T2 mapping(map) value and fat fraction(FF) values of the vertebral(V) and nu cleus pulposus(NP) within the Pfirrmann Ⅰ and Pfirrmann Ⅱ intervertebral disc(grade Ⅰ 76,grade Ⅱ 87) were statistically analyzed.Receiver operating characteristic(ROC) curve analyses were performed for meaningful parameters.Results V-FF showed a mild positive correlation with degenerative intervertebral disc lesions,and NP-FF and NP-map values showed a mild negative correlation with lesions.There were statistically significant differences between the two groups in V-FF(P<0.001),NP-FF(P=0.005),and NP-map(P<0.001).Some measurements had statistically significant differences when different intervertebral disc segments were compared.Conclusion V-FF,NP-FF,and NP-map are associated with intervertebral disc degeneration.T2 mapping and mDixon Quant are potentially valuable as diagnostic tools to quantitatively assess early intervertebral disc degeneration and help diagnose.更多还原