【摘要】 CD8~+T细胞耗竭是导致机体免疫应答减弱及恶性肿瘤复发转移的核心原因。T细胞不仅在迁移进入肿瘤微环境(tumor microenvironment, TME)时需要突破重重屏障，而且在浸润至肿瘤微环境的T细胞的分化及代谢过程依然受到多因素的调控，往往造成CD8~+T细胞抗肿瘤活性受到抑制，进一步形成耗竭性T细胞，导致免疫逃逸。因此，研究导致T细胞耗竭的相关因素及发生机制是逆转机体低免疫应答的关键，为抗肿瘤免疫治疗提供坚实的基础及依据。该文综述了近年来关于CD8~+T细胞在肿瘤微环境中的浸润分化、代谢重编程及耗竭性T细胞形成的相关过程，以期为改善T细胞抗肿瘤疗效提供潜在策略。更多还原

【Abstract】 Depletion of CD8~+T cells is the core cause of weakened immune response and recurrence and metastasis of malignant tumors.T cells not only need to break through multiple barriers when migrating into the tumor microenvironment, but also the differentiation and metabolism of T cells infiltrated in the tumor microenvironment are still regulated by multiple factors, which often leads to the inhibition of anti-tumor activity of CD8~+T cells and further the formation of exhausted T cells,leading to immune escape. Therefore,the study of the related factors and mechanisms leading to T cell depletion is the key to reverse the hypoimmune response in the body,and provides a solid foundation and basis for anti-tumor immunotherapy. In this paper,we reviewed the related processes of infiltration,differentiation,metabolic reprogramming of CD8~+T cells and the formation of depleting T cells in the tumor microenvironment,in order to provide potential strategies for improving the anti-tumor efficacy of T cells.更多还原