【摘要】 肝细胞肝癌肿瘤组织的高度异质性使得肝细胞肝癌患者经常对化疗药物及靶向药物产生耐药。研究表明，上皮间质转化(epithelial-mesenchymal transition, EMT)过程中调控EMT的转录因子、细胞因子及相关的信号通路和一些非编码RNA介导了肝细胞肝癌的耐药。此外，发生EMT的肝细胞显示出类似癌症干细胞的特征—对药物原发耐药。EMT在肝癌耐药的发展中起着不可忽视的作用，为此我们就EMT在肝细胞肝癌耐药机制中的作用及靶向EMT治疗肝细胞肝癌的可行性进行综述。更多还原

【Abstract】 The high heterogeneity of hepatocellular tumor tissue makes hepatocellular carcinoma patients often resistant to chemotherapeutic and targeted drugs.Studies have shown that transcription factors, cytokines and related signaling pathways and some non-coding RNAs that regulate EMT during epithelial-mesenchymal transition mediate the drug resistance of hepatocellular carcinoma.In addition, hepatocytes undergoing EMT displayed characteristics similar to those of cancer stem cells—primary drug resistance.EMT plays an important role in the development of drug resistance in hepatocellular carcinoma.Therefore, we reviewed the role of EMT in the drug resistance mechanism of hepatocellular carcinoma and the feasibility of targeting EMT in the treatment of hepatocellular carcinoma.更多还原