【摘要】 目的:探讨剪接因子3B亚单位1（SF3B1）在乳腺癌组织中的表达及与患者临床病理特征的关系。方法:分析88例乳腺癌患者乳腺癌组织和癌旁组织SF3B1的表达水平，评估SF3B1对乳腺癌的诊断价值，比较SF3B1高表达组与低表达组临床病理特征差异。结果:乳腺癌组织SF3B1表达明显高于癌旁组织（P<0.05）;SF3B1诊断乳腺癌的AUC为0.713;SF3B1诊断乳腺癌的最佳截断值为110.72。高表达组年龄明显高于低表达组，淋巴结转移为N₀的比例明显低于低表达组，两组病理学分级比较差异有统计学意义（P<0.05）。结论:SF3B1在乳腺癌组织中的表达明显上调，在诊断乳腺癌方面效能较好，与临床病理参数有关，可能参与了乳腺癌的发生、侵袭和转移过程的调控。更多还原

【Abstract】 Objective:To analyze the expression of splicing factor 3B subunit 1（SF3B1） in breast cancer tissues and its relationship with clinicopathology.Methods:The expression levels of SF3B1 in breast cancer tissues and adjacent non-tumor tissues were compared in 88 breast cancer patients, evaluate the diagnostic value of SF3B1 for breast cancer.The differences in clinicopathological characteristics between the high-and low-SF3B1 expression groups were compared.Results:The expression of SF3B1 in breast cancer tissues was significantly higher than that in adjacent tissues（P<0.05）.The AUC of SF3B1 for diagnosis of breast cancer was 0.713.The best cut-off value of SF3B1 for the diagnosis of breast cancer was 110.72.The age of the high-SF3B1 expression group was significantly higher than that of the low-SF3B1 expression group, the proportion of lymph node metastasis to N₀ was significantly lower than that of the low-SF3B1 expression group, and there was significant difference in pathological grade between the two groups（all P<0.05）.Conclusion:The expression of SF3B1 is significantly up-regulated in breast cancer tissues and has a good diagnostic efficacy in breast cancer.SF3B1 is related to clinicopathological parameters and may be involved in the regulation of the occurrence, invasion and metastasis of breast cancer.更多还原