【摘要】 目的：探讨慢性牙周炎伴咬合创伤患者龈沟液骨硬化蛋白（Sclerostin）、神经轴突导向因子3(SLIT3)与牙周临床指标和核因子-κb受体活化因子配体（RANKL）-骨保护蛋白（OPG）系统的相关性。方法：选择2021年1月至2023年1月我院收治的123例慢性牙周炎伴咬合创伤患者（创伤组）和101例不伴咬合创伤的慢性牙周炎患者（对照组）。治疗前，检测龈沟液中Sclerostin、SLIT3、RANKL、OPG水平，计算RANKL/OPG比值，评估临床牙周指标出血指数（SBI）、菌斑指数（PLI）、探诊深度（PD）、附着丧失（AL）。分析Sclerostin、SLIT3与牙周临床指标、RANKL、OPG、RANKL/OPG之间的相关性。结果：创伤组治疗前龈沟液中Sclerostin、SLIT3、RANKL水平，RANKL/OPG,PLI、SBI、AL、PD高于对照组（P<0.05）,OPG低于对照组（P<0.05）。创伤组治疗前龈沟液中Sclerostin、SLIT3与PLI、SBI、AL、PD、RANKL、RANKL/OPG呈正相关（P<0.05），与OPG呈负相关（P<0.05）。结论：慢性牙周炎伴咬合创伤患者龈沟液中Sclerostin、SLIT3水平显著增高，且与牙周临床指标异常、RANKL/OPG增加有关。更多还原

【Abstract】 Objective: To investigate the correlation of sclerostin and nerve axon guidance factor 3(SLIT3) in gingival crevicular fluid with periodontal clinical indicators and nuclear factor-κb receptor activator ligand(RANKL)-osteoprotegerin(OPG) system in patients with chronic periodontitis and occlusal trauma. Methods: 123 patients with chronic periodontitis and occlusal trauma(trauma group) and 101 patients with chronic periodontitis without occlusal trauma(control group) who were admitted to our hospital from January 2021 to January 2023 were selected. Before treatment, the levels of Sclerostin, SLIT3, RANKL and OPG in gingival crevicular fluid were detected, the ratio of RANKL/OPG was calculated, and the clinical periodontal indexes such as bleeding index(SBI), plaque index(PLI), probing depth(PD) and attachment loss(AL) were evaluated. The correlation between Sclerostin, SLIT3 and periodontal clinical indicators, RANKL, OPG, RANKL/OPG was analyzed. Results: The levels of Sclerostin, SLIT3, RANKL, RANKL/OPG, PLI, SBI, AL and PD in gingival crevicular fluid in trauma group before treatment were higher than those in control group(P<0.05), and OPG was lower than that in control group(P<0.05). Sclerostin and SLIT3 in gingival crevicular fluid in trauma group were positively correlated with PLI,SBI, AL, PD, RANKL and RANKL/OPG ratio before treatment(P<0.05), and negatively correlated with OPG(P<0.05). Conclusion: The levels of Sclerostin and SLIT3 in gingival crevicular fluid of patients with chronic periodontitis and occlusal trauma are significantly increase, which is relate to the abnormal periodontal clinical indicators and the increase of RANKL/OPG.更多还原