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火龙果果皮多糖对小鼠抗运动疲劳作用的研究
Anti Exercise Fatigue Effect of Hylocereus Undulatus Britt. Peel Polysaccharides on Mice
【摘要】 目的:火龙果果皮是火龙果的主要副产品,具有显著的生物活性。文章探讨不同剂量火龙果果皮多糖(Hylocereus undulatus Britt.peel polysaccharides,HPP)对小鼠的抗疲劳作用及其机制。方法:选取SPF级雄性昆明种小鼠100只,共设置5组:空白对照组、模型组及低、中、高剂量组HPP(100、200、400 mg/kg)。结果:抗氧化活性试验表明,HPP具有一定的抗氧化能力。动物试验表明,HPP不同剂量组可显著延长小鼠疲劳转棒和负重力竭游泳时间,使运动后小鼠肝糖原和肌糖原的储备量明显增加,提高乳酸脱氢酶(Lactate dehydrogenase,LDH)活性,并有效抑制代谢产物血乳酸(Blood lactic acid,BLA)和血尿素氮(Blood urea nitrogen,BUN)含量的堆积(P<0.05),且可提高超氧化物歧化酶(Superoxide dismutase,SOD)、过氧化氢酶(Catalase,CAT)和谷胱甘肽过氧化物酶(Glutathione peroxidase,GSH-Px)活性(P<0.05),降低活性氧自由基(Reactive oxygen species,ROS)、肌酸激酶(Creatine kinase,CK)和丙二醛(Malondialdehyde,MDA)含量。结论:添加HPP有利于缓解机体运动性疲劳,为HPP在医药和功能食品中的开发和应用提供了基础依据。
【Abstract】 Objective:The peel of Hylocereus undulatus Britt.was the main by-product of pitaya,exhibits significant biological activity.The study investigated the anti-fatigue effects and mechanisms of different doses of Hylocereus undulatus Britt.peel polysaccharides (HPP) in mice.Method:100 SPF grade male Kunming mice were divided into five groups:blank control group,model group,and low,medium,high dose groups of HPP (100,200,400 mg/kg).Result:The antioxidant activity test indicates that HPP had a certain degree of antioxidant ability.Animal experiments had shown that different dosage groups of HPP can significantly prolong the time of fatigue rotation and weight-bearing exhaustive swimming in mice,significantly increase the reserve of liver glycogen and muscle glycogen after exercise,increase the activity of lactate dehydrogenase (LDH),and effectively inhibit the accumulation of metabolic products such as blood lactic acid (BLA) and blood urea nitrogen (BUN) (P<0.05),and it can increase the activities of superoxide dismutase (SOD),catalase (CAT),and glutathione peroxidase (GSH-Px) (P<0.05),and reduce the content of reactive oxygen species (ROS),creatine kinase (CK),and malondialdehyde (MDA).Conclusion:Adding HPP was beneficial for alleviating exercise induced fatigue in organisms,thus providing a basic basis for the development and application of HPP in medicine and functional foods.
【Key words】 Hylocereus vulgatus Britt.peel polysaccharides; anti fatigue; antioxidant activity; exercise;
- 【文献出处】 食品科技 ,Food Science and Technology , 编辑部邮箱 ,2024年04期
- 【分类号】TS209;TS201.4
- 【下载频次】118